OUR LATEST NEWS

Scientific Communication Program ConCiencia from Canal Sur. «Sleep Well, Eat Well»

Members of our research group have been interviewed by the television channel Canal Sur for the science communication program ConCiencia. There, they have spoken about their latest advances in their research on melatonin and its benefits for the prevention of obesity and diabetes focusing on thermogenic tissues (adipose and skeletal muscle) as a promising therapeutic target to combat this pandemic.

You can see the complete program at the following link.

https://www.canalsur.es/television/programas/conciencia/noticia/2046872.html

IV Symposium on Advanced Therapies and Biomedical Technologies

Last November 28th, José Juan Ángel-Morillo participated in the VI Symposium on Advanced Therapies and Biomedical Technologies with a poster entitled: “Melatonin Ameliorates Heart Failure by Improving Ventricular Remodeling and Ejection Fraction in Male ZDF Rats”.

IV Levant Endocrinology and Diabetes Congress

From November 11th to 14th, 2025, Dr. Ahmad Agil attended as a guest speaker at the 4th Levant Endocrinology and Diabetes Congress in Jordan with an oral presentation entitled «Targeting Mitochondria (Thermogenesis) to Improve Obesity & its Metabolic Complications: The role of lifestyle and Melatonin».

VI Symposium on Precision Medicine, IBsGranada

On Thursday, October 30, 2025, two members of our research group attended the VI Symposium on Precision Medicine organized by IBS Granada at the Faculty of Medicine of the University of Granada. At this conference, José Juan and Diego presented a poster entitled “Melatonin protects from heart failure by improving cellular stress and mitochondrial function in obese diabetic ZDF rats.”

ALECSO Project Meeting in Support of Development

Dr. Ahmad Agil attended as a guest speaker at the ALECSO Project Meeting in Support of Development 2025, held from October 28 to 30, 2025, at the University of Nouakchott, Mauritania, with an oral presentation entitled «Targeting Mitochondria (Thermogenesis) to Improve Obesity & its Metabolic Complications: The role of lifestyle and Melatonin.»

1st Seminar of the Neuroscientific Club of the Federico Oloriz Institute of Neurosciences 2025

On Thursday, October 23, 2025, our PhD student Diego Salagre Simón presented part of his research work in a talk entitled “Interorganellar signaling and communication in the circadian syndrome. Role of melatonin.”
The presentation was held in the Salón de Grados of the Biomedical Research Center (CIBM) at the University of Granada (UGR) as part of the 1st Seminar of the Neuroscientific Club of the Federico Oloriz Institute of Neurosciences. The talk was attended by professors, researchers, and students from the UGR’s Master’s Degree in Basic, Applied, and Pain Neurosciences.

3rd GRANAMET Meeting

On September 12th 2025, our research group attended and participated in the 3rd GranaMet meeting in Granada. The Granada Network of Translational Research in Metabolism (GRANAMET) is based on a translational approach that spans from the investigation of molecules and the cellular environment to clinical research, thus allowing to face great challenges in metabolic research. In the meeting, our PhD student Diego Salagre introduced the lines of research from our team and presented some of the results of his thesis. The title of his communication was: «Skeletal muscle non-shivering thermogenesis as a promising therapeutic target against diabesity. Role of Melatonin».

Here are some pictures of this scientific meeting:

XV Reunión de Jóvenes Farmacólogos de Andalucía

  • On June 27th 2025, our research group attended and participated in the XV Reunión de Jóvenes Farmacólogos de Andalucía (RJFA) in Seville. In it, the group presented 2 oral communications one by our PhD student Diego Salagre, and another by our Master student Clara Rubio. The title of both communication were: 1.-«Melatonin promotes mitochondria-ER contacts and restores organellar membrane phospholipid composition in the skeletal muscle from both sex Zücker diabetic fatty rats», and 2.-«Effect of melatonin on adipose tissue-derived mesenchymal stem cells (AT-MSCs) chondrogenic differentiation».

    Here are some pictures of this scientific meeting:

I CarMeN Laboratory Young Researchers Conference

On May 21th 2025, our PhD Student participated with 2 communications in the I CarMeN Laboratory Young Researchers Conference during his international research stay. The title of both communications were: «Non-Shivering Thermogenesis as a promising therapeutic target against Diabesity. Role of Melatonin», and «I have a dream…».

Here are some pictures of this scientific meeting:

Melatonin protects against muscle damage and restores the proportion of fibers altered by obesity and diabetes, according to an University of
Granada study.

Members of our research group have published in media the latest results of the research project we are carrying out on the beneficial effects of melatonin in muscle damage prevention and fiber composition restoration in «Diabesity». To increase the global reach of this news and to be able top disseminate our results to the entire world society, we have translated the press release into several languages and you can access them by clicking on each of the versions indexed below:

V Symposium on Advanced Therapies and Biomedical Technologies (ibs.GRANADA)

On December 20th 2024, our research group attended and participated in the V Symposium on Advanced Therapies and Biomedical Technologies (ibs.GRANADA). In it, the group presented 2 poster communications one by our PhD student Diego Salagre and Master student Clara Rubio. The title of both communication were: 1.-«Organelle-Molecular Mechanisms of Muscle Non-Shivering Thermogenesis in Response to Melatonin in Obese Diabetic ZDF Rats», and 2.-«Melatonin activates human skeletal muscle calcium-dependent thermogenesis in vitro: role of melatonin receptor 2».

Here are some pictures of this scientific meeting:

«Thermogenic tissues as therapeutic target for obesity and its complications: style of life and melatonin role» – Dr. Ahmad Agil

Our Research Group Director Prof. Dr. Ahmad Agil has participated in the 4th International Medical Congress in Almafraq-Jordan from 1st to 5th August 2024 organized by the SubCommittee of the Medical  Association with his talk entitled: “Thermogenic tissues as therapeutic target obesity and its complications: style of life and melatonin role”
 

Researchers from the University of Granada shows the positive effects of melatonin on the obesity prevention

Members of our research group have published in several Spanish newspapers and other media the latest results of the research project we are carrying out on the beneficial effects of melatonin in the prevention of obesity and Type 2 Diabetes.

Diego Salagre, member of our Research group, winner of the 3 Minutes Thesis competition at the University of Granada

Our Research Group Mr. Diego Salagre has participated in the 3 minutes thesis (3MT) competition with his talk entitle: «I have a dream» and been awarded with the first prize. The final was celebrated in Granada March 18th.

OUR LATEST PUBLICATIONS

Salagre D, Navarro-Alarcón M, González LG, Elrayess MA, Villalón-Mir M, Haro-López R, Agil A.

Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats. Antioxidants 2025, 14, 16.

https://doi.org/10.3390/antiox14010016

Salagre D, Bajit H, Fernández-Vázquez G, Dwairy M, Garzón I, Haro-López R, Agil A.

Melatonin induces fiber switching by improvement of mitochondrial oxidative capacity and function via NRF2/RCAN/MEF2 in the vastus lateralis muscle from both sex Zücker diabetic fatty rats. Free Radic Biol Med. 2024 Dec 5;227:322-335.

doi: 10.1016/j.freeradbiomed.2024.12.019.

Salagre D, Navarro-Alarcón M, Villalón-Mir M, Alcázar-Navarrete B, Gómez-Moreno G, Tamimi F, Agil A.

Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats. Biomed Pharmacother. 2024 Mar;172:116314.

doi: 10.1016/j.biopha.2024.116314.  doi: 10.1016/j.biopha.2024.116411.

Sánchez-Borja C, Cristóbal-Cañadas D, Rodríguez-Lucenilla MI, Muñoz-Hoyos A, Agil A, Vázquez-López MÁ, Parrón-Carreño T, Nievas-Soriano BJ, Bonillo-Perales A, Bonillo-Perales JC. Lower plasma melatonin levels in non-hypoxic premature newborns associated with neonatal pain. Eur J Pediatr. 2024 Aug;183(8):3607-3615.

doi: 10.1007/s00431-024-05632-1.

Salagre D, Raya Álvarez E, Cendan CM, Aouichat S, Agil A. Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat. Antioxidants (Basel). 2023 Jul 27;12(8):1499.

doi: 10.3390/antiox12081499. 

 

Diéguez E, Nieto-Ruiz A, Sepúlveda-Valbuena A, Herrmann F, Agil A , De-Castellar R, Jiménez J, Azaryah H, García-Santos JA, García-Bermúdez M and Campoy C.

Long-term effects and potential impact of early nutrition with breast milk or infant formula on glucose homeostasis control in healthy children at 6 years old: a follow-up from the COGNIS study. Nutrients 2023, 15(4), 852; 

https://doi.org/10.3390/nu15040852

Alsharif KF, Albrakati A, Al Omairi NE, Almalki AS, Alsanie WF, Elmageed ZYA, Habotta OA, Lokman MS, Althagafi HA, Alghamdi AAA, Moneim AEA, Alyami H, Belal SKM, Alnefaie G, Alamri AS, Albezrah NKA, Kassab RB, Albarakati AJA, Hassan KE, Agil A. 

Therapeutic antischizophrenic activity of prodigiosin and selenium co-supplementation against amphetamine hydrochloride-induced behavioral changes and oxidative, inflammatory, and apoptotic challenges in rats. Environ Sci Pollut Res Int. 2023.30(3):7987-8001.

doi: 10.1007/s11356-022-22409-x

 
Aouichat S, Raya E, Molina-Carballo A, Munoz-Hoyos A, Saleh Aloweidi A, Elmahallawy KE, Agil A (corresponding autor). 

Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zücker Diabetic Fatty Rat: Future Clinical Implications for Obesity. Antioxidants. 2022.

DOI: 10.3390/cimb44010003.

 
Salagre D, Chayah M, Molina-Carballo A, Oliveras-López MJ, Munoz-Hoyos A, Navarro-Alarcón M, Fernández-Vázquez G, Agil A (corresponding autor). 

Melatonin induces fat browning by transdifferentiating white adipocytes and de novo differentiation of mesenchymal stem cells. Food Funct. 2022. 21;13(6):3760-3775.