Scientific Communication Program ConCiencia from Canal Sur. «Sleep Well, Eat Well»
Members of our research group have been interviewed by the television channel Canal Sur for the science communication program ConCiencia. There, they have spoken about their latest advances in their research on melatonin and its benefits for the prevention of obesity and diabetes focusing on thermogenic tissues (adipose and skeletal muscle) as a promising therapeutic target to combat this pandemic.
You can see the complete program at the following link.
https://www.canalsur.es/television/programas/conciencia/noticia/2046872.html
Melatonin protects against muscle damage and restores the proportion of fibers altered by obesity and diabetes, according to an University of
Granada study.
Members of our research group have published in media the latest results of the research project we are carrying out on the beneficial effects of melatonin in muscle damage prevention and fiber composition restoration in «Diabesity». To increase the global reach of this news and to be able top disseminate our results to the entire world society, we have translated the press release into several languages and you can access them by clicking on each of the versions indexed below:
- Spanish: La melatonina protege contra el daño muscular y restablece la proporción de fibras alteradas por la obesidad y la diabetes, según un estudio de la UGR
- English: Melatonin protects against muscle damage and restores the proportion of fibers altered by obesity and diabetes
- الميلاتونين يحمي من التلف العضلات ويستعيد توازن ألياف المتأثر بالسمنة والسكري، وفقًا لدراسة من جامعة غرناطة : Arab
- French: La mélatonine protège contre les dommages musculaires et rétablit l’équilibre des fibres altéré par l’obésité et le diabète, selon une étude de l’Université de Grenade
- Italian: La melatonina protegge dai danni muscolari e ripristina l’equilibrio delle fibre alterato da obesità e diabete, secondo uno studio dell’Università di Granada
- Greek: Η μελατονίνη προστατεύει από τις μυϊκές βλάβες και αποκαθιστά την ισορροπία των ινών που αλλοιώνονται από την παχυσαρκία και τον διαβήτη, σύμφωνα με μελέτη του Πανεπιστημίου της Γρανάδας
- Portuguese: A melatonina protege contra danos musculares e restaura o equilíbrio das fibras alterado pela obesidade e diabetes, segundo um estudo da Universidade de Granada
V Symposium on Advanced Therapies and Biomedical Technologies (ibs.GRANADA)
On December 20th 2024, our research group attended and participated in the V Symposium on Advanced Therapies and Biomedical Technologies (ibs.GRANADA). In it, the group presented 2 poster communications one by our PhD student Diego Salagre and Master student Clara Rubio. The title of both communication were: 1.-«Organelle-Molecular Mechanisms of Muscle Non-Shivering Thermogenesis in Response to Melatonin in Obese Diabetic ZDF Rats», and 2.-«Melatonin activates human skeletal muscle calcium-dependent thermogenesis in vitro: role of melatonin receptor 2».
Here are some pictures of this scientific meeting:
«Thermogenic tissues as therapeutic target for obesity and its complications: style of life and melatonin role» – Dr. Ahmad Agil
Our Research Group Director Prof. Dr. Ahmad Agil has participated in the 4th International Medical Congress in Almafraq-Jordan from 1st to 5th August 2024 organized by the SubCommittee of the Medical Association with his talk entitled: “Thermogenic tissues as therapeutic target obesity and its complications: style of life and melatonin role”
Researchers from the University of Granada shows the positive effects of melatonin on the obesity prevention
Members of our research group have published in several Spanish newspapers and other media the latest results of the research project we are carrying out on the beneficial effects of melatonin in the prevention of obesity and Type 2 Diabetes.
- Spanish_ Investigadores de la UGR demuestran el efecto positivo de la melatonina en la prevención de la obesidad
- English_ Researchers from UGR shows the positive effect of melatonin en the obesity prevention
- أثبت باحثو جامعة غرناطة Arab
- Français_Des rechercheurs de l’Université de Grenade démontrent l’effet positif de la mélatonine dans la prévention de l’obésité
Diego Salagre, member of our Research group, winner of the 3 Minutes Thesis competition at the University of Granada
Our Research Group Mr. Diego Salagre has participated in the 3 minutes thesis (3MT) competition with his talk entitle: «I have a dream» and been awarded with the first prize. The final was celebrated in Granada March 18th.
OUR LATEST PUBLICATIONS
Salagre D, Navarro-Alarcón M, González LG, Elrayess MA, Villalón-Mir M, Haro-López R, Agil A.
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats. Antioxidants 2025, 14, 16.
https://doi.org/10.3390/antiox14010016
Salagre D, Bajit H, Fernández-Vázquez G, Dwairy M, Garzón I, Haro-López R, Agil A.
Melatonin induces fiber switching by improvement of mitochondrial oxidative capacity and function via NRF2/RCAN/MEF2 in the vastus lateralis muscle from both sex Zücker diabetic fatty rats. Free Radic Biol Med. 2024 Dec 5;227:322-335.
doi: 10.1016/j.freeradbiomed.2024.12.019.
Salagre D, Navarro-Alarcón M, Villalón-Mir M, Alcázar-Navarrete B, Gómez-Moreno G, Tamimi F, Agil A.
Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats. Biomed Pharmacother. 2024 Mar;172:116314.
doi: 10.1016/j.biopha.2024.116314. doi: 10.1016/j.biopha.2024.116411.
Sánchez-Borja C, Cristóbal-Cañadas D, Rodríguez-Lucenilla MI, Muñoz-Hoyos A, Agil A, Vázquez-López MÁ, Parrón-Carreño T, Nievas-Soriano BJ, Bonillo-Perales A, Bonillo-Perales JC. Lower plasma melatonin levels in non-hypoxic premature newborns associated with neonatal pain. Eur J Pediatr. 2024 Aug;183(8):3607-3615.
doi: 10.1007/s00431-024-05632-1.
Salagre D, Raya Álvarez E, Cendan CM, Aouichat S, Agil A. Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat. Antioxidants (Basel). 2023 Jul 27;12(8):1499.
doi: 10.3390/antiox12081499.
Diéguez E, Nieto-Ruiz A, Sepúlveda-Valbuena A, Herrmann F, Agil A , De-Castellar R, Jiménez J, Azaryah H, García-Santos JA, García-Bermúdez M and Campoy C.
Long-term effects and potential impact of early nutrition with breast milk or infant formula on glucose homeostasis control in healthy children at 6 years old: a follow-up from the COGNIS study. Nutrients 2023, 15(4), 852;
https://doi.org/10.3390/nu15040852
Alsharif KF, Albrakati A, Al Omairi NE, Almalki AS, Alsanie WF, Elmageed ZYA, Habotta OA, Lokman MS, Althagafi HA, Alghamdi AAA, Moneim AEA, Alyami H, Belal SKM, Alnefaie G, Alamri AS, Albezrah NKA, Kassab RB, Albarakati AJA, Hassan KE, Agil A.
Therapeutic antischizophrenic activity of prodigiosin and selenium co-supplementation against amphetamine hydrochloride-induced behavioral changes and oxidative, inflammatory, and apoptotic challenges in rats. Environ Sci Pollut Res Int. 2023.30(3):7987-8001.
doi: 10.1007/s11356-022-22409-x
Aouichat S, Raya E, Molina-Carballo A, Munoz-Hoyos A, Saleh Aloweidi A, Elmahallawy KE, Agil A (corresponding autor).
Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zücker Diabetic Fatty Rat: Future Clinical Implications for Obesity. Antioxidants. 2022.
DOI: 10.3390/cimb44010003.
Salagre D, Chayah M, Molina-Carballo A, Oliveras-López MJ, Munoz-Hoyos A, Navarro-Alarcón M, Fernández-Vázquez G, Agil A (corresponding autor).
Melatonin induces fat browning by transdifferentiating white adipocytes and de novo differentiation of mesenchymal stem cells. Food Funct. 2022. 21;13(6):3760-3775.