Publications
Salagre D, Navarro-Alarcón M, González LG, Elrayess MA, Villalón-Mir M, Haro-López R, Agil A.
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats. Antioxidants 2025, 14, 16. https://doi.org/10.3390/antiox14010016
Salagre D, Bajit H, Fernández-Vázquez G, Dwairy M, Garzón I, Haro-López R, Agil A.
Melatonin induces fiber switching by improvement of mitochondrial oxidative capacity and function via NRF2/RCAN/MEF2 in the vastus lateralis muscle from both sex Zücker diabetic fatty rats. Free Radic Biol Med. 2024 Dec 5;227:322-335. doi: 10.1016/j.freeradbiomed.2024.12.019.
Salagre D, Navarro-Alarcón M, Villalón-Mir M, Alcázar-Navarrete B, Gómez-Moreno G, Tamimi F, Agil A.
Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats. Biomed Pharmacother. 2024 Mar;172:116314.
doi: 10.1016/j.biopha.2024.116314. doi: 10.1016/j.biopha.2024.116411.
Sánchez-Borja C, Cristóbal-Cañadas D, Rodríguez-Lucenilla MI, Muñoz-Hoyos A, Agil A, Vázquez-López MÁ, Parrón-Carreño T, Nievas-Soriano BJ, Bonillo-Perales A, Bonillo-Perales JC. Lower plasma melatonin levels in non-hypoxic premature newborns associated with neonatal pain. Eur J Pediatr. 2024 Aug;183(8):3607-3615.
doi: 10.1007/s00431-024-05632-1.
Salagre D, Raya Álvarez E, Cendan CM, Aouichat S, Agil A. Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat. Antioxidants (Basel). 2023 Jul 27;12(8):1499.
doi: 10.3390/antiox12081499.
Diéguez E, Nieto-Ruiz A, Sepúlveda-Valbuena A, Herrmann F, Agil A , De-Castellar R, Jiménez J, Azaryah H, García-Santos JA, García-Bermúdez M and Campoy C.
Long-term effects and potential impact of early nutrition with breast milk or infant formula on glucose homeostasis control in healthy children at 6 years old: a follow-up from the COGNIS study. Nutrients 2023, 15(4), 852; https://doi.org/10.3390/nu15040852
Alsharif KF, Albrakati A, Al Omairi NE, Almalki AS, Alsanie WF, Elmageed ZYA, Habotta OA, Lokman MS, Althagafi HA, Alghamdi AAA, Moneim AEA, Alyami H, Belal SKM, Alnefaie G, Alamri AS, Albezrah NKA, Kassab RB, Albarakati AJA, Hassan KE, Agil A.
Therapeutic antischizophrenic activity of prodigiosin and selenium co-supplementation against amphetamine hydrochloride-induced behavioral changes and oxidative, inflammatory, and apoptotic challenges in rats. Environ Sci Pollut Res Int. 2023.30(3):7987-8001. doi: 10.1007/s11356-022-22409-x
Aouichat S, Raya E, Molina-Carballo A, Munoz-Hoyos A, Saleh Aloweidi A, Elmahallawy KE, Agil A (corresponding autor).
Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zücker Diabetic Fatty Rat: Future Clinical Implications for Obesity. Antioxidants. 2022. DOI: 10.3390/cimb44010003.
Salagre D, Chayah M, Molina-Carballo A, Oliveras-López MJ, Munoz-Hoyos A, Navarro-Alarcón M, Fernández-Vázquez G, Agil A (corresponding autor).
Melatonin induces fat browning by transdifferentiating white adipocytes and de novo differentiation of mesenchymal stem cells. Food Funct. 2022. 21;13(6):3760-3775.
Molina-Carballo A, Palacios-Lopez R, Jerez-Calero A, Augustin-Morales MC, Agil A, Munoz-Hoyos A, Munoz-Gallego A.
Protective Effect of Melatonin Administration against SARS-CoV-2 Infection: A Systematic Review. Curr. Issues Mol. Biol. 2022. 44 (1). 31-45
Agil A (corresponding author). Navarro-Alarcon M, Ali FAZ, Albrakati A, Salagre D, Campoy C, Elmahallawy EK.
Melatonin Enhances the Mitochondrial Functionality of Brown Adipose Tissue in Obese-Diabetic Rats. Antioxidants. 2021. 17; 10(9):1482.
Navarro-Alarcón M, Gil-Hernández F, Sánchez-González C, Llopis J, Villalón-Mir M, Olmedo P, Alarcón-Guijo P, Salagre P, Gaona L, Paredes M, Agil A (corresponding autor).
Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats. Pharmaceutics. 2021. 13 (10, 1535.
Aouichat S, Chayah M, Bouguerra-Aouichat S, Agil A (corresponding autor). 2020.
Time-restricted Feeding Improves body weight gain, lipid profile, and atherogenic Indices in Cafeteria Diet-fed Rats: Role of browning Inguinal White Adipose Tissue. Nutrients. 23; 12(8):2185.
Agil A (corresponding autor), Chayah M, Visiedo L, Navarro-Alarcon M, Reiter JR, Fernández-Vázquez G. 2020.
Melatonin improves the mitochondrial dynamics and functions in the kidney of Zuker diabetic fatty rats. J Clin Med. 10; 9(9):E2916.
Elmahallawy EK, Elshopakey GE, Saleh AA, Agil A, El-Morsey A, El-Shewehy DMM, Sad AS, Yanai T, Abdo W. 2020.
S-Methylcysteine (SMC) Ameliorates Intestinal, Hepatic, and Splenic Damage Induced by Cryptosporidium parvum Infection via Targeting Inflammatory Modulators and OxidativeStress in Swiss Albino Mice. Biomedicines. 15; 8(10):423.
García‐Galdeano JM, Villalón‐Mir M, Medina‐Martínez J, Vázquez‐Foronda LM, Zamora‐Bustillos JG, Agil A, Moor‐Davie SM, Navarro‐Alarcón M.
Zn, Cu, and Fe Concentrations in Dehydrated Herbs (Thyme, Rosemary, Cloves, Oregano, and Basil) and the Correlation with the Microbial Counts of Listeria monocytogenes and Other Foodborne pathogens. Foods. 1658; doi:10.3390/ foods9111658.
Fernandez Vazquez G , Reiter RJ , Agil A (corresponding autor).
Melatonin increases brown adipose tissue mass and functionality in Zücker diabetic fatty rats: implications for obesity control. Journal of Pineal Research. 2018 Feb 6. doi: 10.1111 / jpi.12472.
Alarcon-Navarro M, Villalon M, Jones C, Quesada-Granados J, Agil A (corresponding autor). 2018.
Melatonin increases magnesium concentrations in white adipose tissue and pancreas of diabetic obese rats. Journal of Functional Foods. 2018. (48)167-172.
Campos D, Hernández-Torres JJ, Agil A, Comino M, López JC, Macías V, Campoy C.
Analysis of food advertising to children on Spanish television: probing exposure to television marketing. Arch Med Sci. 2016 Aug 1;12(4):799-807. doi: 10.5114/aoms.2016.60969. Epub 2016 Jul 1.PMID: 27478462 799–807. 2016.
Masocha W, Gonzalez GL, Agil A (corresponding autor).
Distinguishing subgroups among μ-opioid receptor agonists using Na+,K+-ATPase as an effector mechanism. European Journal of Pharmacology. 2016 Mar 5; 774:43-9. doi: 10.1016/j.ejphar. 2016. 01.010. Epub 2016 Jan 26.PMID: 26825542
Elmahallawy EK, Luque JO, Aloweidi AS, Fernández JG, Martínez AS, Rodriguez-Granger J, Kaki A, Agil A (corresponding autor).
Potential relevance of melatonin against some infectious agents: A Review and Assessment of Recent Research. Curr Med Chem. 2015; 22(33):3848-61.PMID: 26310920
Berglund sk, García-valdés l, Torres-espinola fj, Segura mt, Martínez-zaldívar c, aguilar mj, Agil a, Lorente ja, Florido j, Padilla c, Altmäe s, marcos a, lópez-sabater mc, campoy c; Preobe Team.
Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (preobe). BMC public health. 2016 mar 1; 16:207. doi: 10.1186/s12889-016-2809-3.pmid: 26931143
Torres-Espínola FJ, Altmäe S, Segura MT, Jerez A , Anjos Tania, Chisaguano M, López-Sabater MC, Entrala C , Alvarez JC, Agil A , Florido J, Catena A, Pérez-García M, Campoy M.
Maternal PPARG Pro12Ala polymorphism is associated with infant’s neurodevelopmental outcomes at 18 months of age. Early Hum Dev. 2015 Aug; 91(8):457-62. doi:10.1016/j.earlhumdev.2015.05. 001. Epub 2015 May 26.PMID: 26025336.
Catena A, Pérez-García M, Lorente JA, Alvarez JC, Agil A, Marcos A, Nova E, López-Sabater MC, Entrala C, McArdle H, Symonds M, Koletzko B, Demmelmair H, Uhl O, Desoye G, Rueda R, Berglund SK).
Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age-A Follow Up from the PREOBE Cohort. PLoS One. 2015 Jul 24; 10(7): e0133010. doi: 0.1371/journal. pone.0133010. eCollection 2015.PMID: 26208217.
Elmahallawy EK, Agil A (corresponding author).
Treatment of Leishmaniasis: A Review and Assessment of Recent Research. Curr Pharm Des. 2015; 21(17):2259-75.PMID: 25543123.
(I. F: 3,052, Pharmacoloy & Pharmacy (9/57; Q1; Nº de citaciones 6)
Agil A (corresponding author), Elmahallawy EK, Rodríguez-Ferrer JM, Adem A, Bastaki SM, Al-Abbadi I, Fino Solano YA, Navarro-Alarcón M.
Melatonin increases intracellular calcium in the liver, muscle, white adipose tissues and pancreas of diabetic obese rats. Food Function. 2015 Aug; 6(8):2671-8. doi: 10.1039/c5fo00590f. Epub 2015 Jul 2.
Agil A (corresponding author), El-Hammadi M, Jiménez-Aranda A, Tassi M, Abdo W, Fernández-Vázquez G, Reiter RJ.
Melatonin Reduces Hepatic Mitochondrial Dysfunction in Diabetic Obese Rats. J Pineal Res. 2015 Aug; 59(1):70-9. doi: 10.1111/jpi.12241. Epub 2015 May 14.PMID: 25904243
Román S, Agil A (corresponding author), Perán M, Alvaro-Galue E, Ruiz-Ojeda FG, Marchal JA.
Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders.Transl Res. 2015 Apr; 165(4):464-79. doi: 10.1016/j.trsl.2014.11.002. Epub 2014 Nov 8.PMID: 25433289
Ojha Sh, Alkaabi J, Amir N, Sheikh A, Agil A, Abdelmonem M, Adem A.
Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats. Oxidative Medicine and Cellular Longevit. 2014; 201436. doi: 10.1155/2014/201436. Epub 2014 Sep 14.PMID: 25295146.
Elmahallawy EK, Sampedro Martinez A, Rodriguez-Granger J, Hoyos-Mallecot Y, Agil A, Navarro Mari JM, Gutierrez Fernandez J.
Diagnosis of leishmaniasis. J Infect Dev Ctries. 2014 Aug 13; 8(8):961-72. doi: 10.3855/jidc.4310. Review.PMID: 25116660.
Ramírez A; Boulaiz H; Morata-Tarifa C; Perán M; Jiménez G; Picon-Ruiz M; Agil A; Cruz-López O; Conejo-García A; Campos JM; Sánchez A; García MA; Marchal JA.
HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget. 2014 Jun 15; 5(11):3590-606.PMID: 24946763.
Blanca- Herrera MR, Ruiz-Ojeda FJ, Mohamad-Akeel-Serrano M, Acuna Castroviejo D, Fernández-Vázquez G; Agil A (corresponding autor).
Melatonin and metabolic regulation: a review. Food Funcion., 5 (2806-2832), 2806. 2014. Review
Elmahallawy E, Jiménez-Aranda A, Sampedro Martínez A, Rodriguez-Granger J, Navarro-Alarcón M; Gutiérrez Fernández J, Agil A (corresponding author).
Activity of melatonin against Leishmaniainfantum promastigotes by mitochondrial dependent pathway. Chemico-Biological Interactions. Chemico-Biological Interactions. 2014 Sep 5;220:84-93. doi: 10.1016/j.cbi.2014.06.016. Epub 2014 Jun.25. PMID: 24973643
Reina de la Torre ML, Navarro-Alarcón M, del Moral LM, López-G de la Serrana H, Palomares-Bayo M, Oliveras López MJ, Blanca Herrera RM, Agil A (corresponding autor).
Serum Zn levels and Cu/Zn ratios worsen in hemodialysis patients, implying increased cardiovascular risk: a 2-year longitudinal study. Biol Trace Elem Res. 2014 May;158(2):129-35. doi: 10.1007/s12011-014-9921-y. Epub 2014 Mar 2. PMID: 24585396.
Jimenéz-Aranda A, Fernández-Vázquez G, Serrano MM, Reiter RJ, Agil A (corresponding autor).
Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats. J Pineal Res. 2014 Aug;57(1):103-9. doi: 10.1111/jpi.12147. Epub 2014 Jul 10.PMID: 24867433
Navarro-Alarcon M, Ruiz-Ojeda FJ, Blanca-Herrera RM, Kaki A, Adem A, Agil A (corresponding autor).
Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg in young male Zucker diabetic fatty rats. Food Funct. 2014 Mar; 5(3):512-6. doi: 10.1039/c3fo60389j. PMID: 24441643.
Jiménez-Aranda A, Fernández-Vázquez G, Campos D, Tassi M, Velasco-Perez L, Tan DX, Reiter RJ, Agil A (corresponding autor).
Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats. J Pineal Res. 2013 Nov;55(4):416-23. doi: 10.1111/jpi.12089. Epub 2013 Sep 6. PMID: 24007241.
Agil A (corresponding autor), Reiter RJ, Jiménez-Aranda A, Ibán-Arias R, Navarro-Alarcón M, Marchal JA, Adem A, Fernández-Vázquez G.
Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. J Pineal Res. 2013 May;54(4):381-8. doi: 10.1111/jpi.12012. Epub 2012 Sep 29. PMID: 23020082
Marchal JA, Carrasco E, Ramirez A, Jiménez G, Olmedo C, Peran M, Agil A, Conejo-García A, Cruz-López O, Campos JM, García MÁ.
Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence. Drug Des Devel Ther. 2013 Oct 29; 7:1301-13. doi: 10.2147/DDDT.S51354. eCollection 2013. PMID: 24194639 PMCID: PMC3815003.
Navarro-Alarcon M, Ruiz-Ojeda FJ, Blanca-Herrera RM, Agil A (corresponding autor).
Antioxidant activity of melatonin in diabetes in relation to the regulation and levels of plasma Cu, Zn, Fe, Mn, and Se in Zucker diabetic fatty rats. Nutrition. 2013 May; 29(5):785-9. doi: 10.1016/j.nut.2012.11.005. Epub 2013 Jan 24. PMID: 23352467
Ramírez-Macías I, Marín C, Samti H, Fernández A, Guardia JJ, Zentar H, Agil A, Chahboun R, Alvarez-Manzaneda E, Sánchez-Moreno M.
Taiwaniaquinoid and abietane quinone derivatives with trypanocidal activity against T. cruzi and Leishmania spp. Parasitol Int. 2012 Sep;61(3):405-13. doi: 10.1016/j.parint. 2012. 02.001. Epub 2012 Feb 16. PMID: 22366342.
Agil A (corresponding autor), Rosado I, Ruiz R, Figueroa A, Zen N, Fernández-Vázquez G.
Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats. J Pineal Res. 2012 Mar;52(2):203-10. doi: 10.1111/j.1600-079X.2011.00928.x. Epub 2011 Aug 25. PMID: 21883445.
Gonzalez LG, Masocha W, Sánchez-Fernández C, Agil A (corresponding autor), Ocaña M, Del Pozo E, Baeyens JM.
Changes in morphine-induced activation of cerebral Na(+),K(+)-ATPase during morphine tolerance: biochemical and behavioral consequences. Biochem Pharmacol. 2012 Jun 1; 83(11):1572-81. doi: 10.1016/j.bcp.2012.02.023. Epub 2012 Mar 3. PMID: 22410004.
Navarro-Alarcon M, Zambrano E, Moreno-Montoro M, Agil A, Olalla M.
Duplicate portion sampling combined with spectrophotometric analysis affords the most accurate results when assessing daily dietary phosphorus intake. Nutr Res. 2012 Aug;32(8):573-80. doi: 10.1016/j.nutres.2012.06.013. Epub 2012 Jul 31. PMID: 22935340
Agil A(corresponding autor), Navarro-Alarcón M, Ruiz R, Abuhamadah S, El-Mir MY, Vázquez GF.
Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. J Pineal Res. 2011 Mar;50(2):207-12. doi: 10.1111/j.1600-079X.2010.00830.x. Epub 2010 Nov 19. PMID: 21087312.
Martí del Moral L, Agil A, Navarro-Alarcón M, López-Ga de la Serrana H, Palomares-Bayo M, Oliveras-López MJ.
Altered serum selenium and uric acid levels and dyslipidemia in hemodialysis patients could be associated with enhanced cardiovascular risk. Biol Trace Elem Res. 2011 Dec;144(1-3):496-503. doi: 10.1007/s12011-011-9152-4. Epub 2011 Jul 26. PMID: 2178954.
Martínez-Peinado M, Nogueras-López F, Arcos-Cebrián A, Agil A, Navarro-Alarcón M.
Serum selenium levels in cirrhotic patients are not influenced by the disease severity index. Nutr Res. 2010 Aug;30(8):574-8. doi: 10.1016/j.nutres.2010.08.004. PMID: 20851312.
Velasco-Reynold C, Navarro-Alarcon M, Lopez-Ga de la Serrana H, Perez-Valero V, Agil A, Lopez-Martinez MC.
Dialysability of magnesium and calcium from hospital duplicate meals: influence exerted by other elements. Biol Trace Elem Res. 2010 Mar;133(3):313-24. doi: 10.1007/s12011-009-8444-4. Epub 2009 Jul 7. PMID: 19582377.
CampoyC , E. Martín-Bautista, L. García-Valdés, J. Florido, A. Agil, J. A. Lorente, A. Marcos, M. C. López-Sabater, T. Miranda-León, Y. Sanz y J. A. Molina-Font.
Estudio de la influencia de la nutrición y genética maternas sobre la programación del desarrollo del tejido adiposo fetal (Estudio PREOBE). Nutr Hosp. 2008 Nov-Dec; 23(6):584-90.PMID: 19132267
Agil A (corresponding author), Durán R, Barrero F, Morales B, Araúzo M, Alba F, Miranda MT, Prieto I, Ramírez M, Vives F.
Plasma lipid peroxidation in sporadic Parkinson’s disease. Role of the L-dopa. J Neurol Sci. 2006 Jan 15;240(1-2):31-6. Epub 2005 Oct 10. PMID: 16219327 DOI: 10.1016/j.jns.2005.08.016
Ruiz JR, Ortega FB, Castillo MJ, Gutierrez A, Agil A (corresponding author).
Increased susceptibility to plasma lipid peroxidation in untrained subjects after an extreme mountain bike challenge at moderate altitude. Int J Sports Med. 2006 Jul;27(7):587-9. PMID: 16802256.
Martínez-Ballesteros C, Pita-Calandre E, Sánchez-González Y, Rodríguez-López CM, Agil A (corresponding autor).
Lipid peroxidation in adult epileptic patients treated with valproic acid. Rev Neurol. 2004 Jan 16-31;38(2):101-6. PMID: 14752705.
Masocha W, Horvath G, Agil A, Ocana M, Del Pozo E, Szikszay M, Baeyens JM.
Role of Na(+), K(+)-ATPase in morphine-induced antinociception. J Pharmacol Exp Ther. 2003 Sep; 306(3):1122-8. Epub 2003 May 19. PMID: 12756273.
Horvath G, Agil A, Joo G, Dobos I, Benedek G, Baeyens JM.
Evaluation of endomorphin-1 on the activity of Na(+),K(+)-ATPase using in vitro and in vivo studies. Eur J Pharmacol. 2003 Jan 5; 458(3):291-7. PMID: 12504785.
Montilla MP, Agil A, Navarro MC, Jiménez MI, García-Granados A, Parra A, Cabo MM.
Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. Planta Med. 2003 May; 69(5):472-4. PMID: 12802735 DOI: 10.1055/s-2003-39698.
Masocha W, González LG, Baeyens JM, Agil A (corresponding author).
Mechanisms involved in morphine-induced activation of synaptosomal Na+,K+-ATPase. Brain Res. 2002 Dec 3; 957(2): 311-9. PMID: 12445973.
Agil A, Sadrzadeh SM.
Hydroxy-urea protects erythrocytes against oxidative damage. Redox Rep. 2000; 5(1):29-34. PMID: 10905541 DOI: 10.1179/rer.2000.5.1.29.
Agil A, Miró M, Jimenez J, Aneiros J, Caracuel MD, García-Granados A, Navarro MC.
Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium. Planta Med. 1999 Oct; 65(7):673-5. PMID: 15609462. DOI: 10.1055/s-2006-960847.
Agil A, Rísco S, Miró M, Navarro MC, Ocete MA, y Jimenez J.
Analgesic and antipyretic effects of Ecballium elaterium (l) A.R. in rodents. Phytotherapy research 9, 135-138. 1995.
Ginsburg GS, Agil A, O’Toole M, Rimm E, Douglas PS, Rifai N.
Effects of a single bout of ultra-endurance exercise on lipid levels and susceptibility of lipids to peroxidation in triathletes.JAMA. 1996 Jul 17; 276(3):221-5.PMID: 8667567
Haffner SM, Miettinen H, Stern MP, Agil A, Jialal I.
Plasma oxidizability in Mexican-Americans and non-Hispanic whites. Metabolism. 1996 Jul; 45(7):876-81.PMID: 8692025
Haffner SM, Agil A, Mykkanen L, Stern MP, Jialal I.
Plasma oxidizability in subjects with normal glucose tolerance, impaired glucose tolerance, and NIDDM. Diabetes Care. 1995 May;18(5):646-53. PMID: 8586002
Agil A, Fuller CJ, Jialal I.
Susceptibility of plasma to ferrous iron/hydrogen peroxide-mediated oxidation: demonstration of a possible Fenton reaction. Clin Chem. 1995 Feb;41(2):220-5.PMID: 7874775.