{"id":2497,"date":"2014-10-08T16:04:21","date_gmt":"2014-10-08T14:04:21","guid":{"rendered":"http:\/\/wdb.ugr.es\/~luisca\/?page_id=2497"},"modified":"2025-12-18T11:05:09","modified_gmt":"2025-12-18T10:05:09","slug":"publications","status":"publish","type":"page","link":"https:\/\/wpd.ugr.es\/~luisca\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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2025-2026<\/h2>\n

D<\/span> istelmaier F, Corral-Sarasa J, Jim\u00e9nez-S\u00e1nchez L, D\u00edaz-Casado ME, Rohmann M, Seibt A, Herebian D, Smits SHJ, M\u00fcnch J, Mayatepek E, Breitkreutz J, Husain RA, L\u00f3pez-Herrador S, Gonz\u00e1lez-Garc\u00eda P, L\u00f3pez LC.
\nPreclinical and first-in-human evidence of 4-hydroxybenzoic acid for mitochondrial COQ2 deficiency. Brain. 2025 Sep 10:awaf334. doi: 10.1093\/brain\/awaf334.<\/p>\n

L<\/span> \u00f3pez-Herrador S, Torres-Rusillo S, Gonz\u00e1lez-Garc\u00eda P, Jim\u00e9nez-S\u00e1nchez L, Corral-Sarasa J, Bakkali M, D\u00edaz-Casado ME, L\u00f3pez LC.
\n\u03b2-Resorcylic acid prevents MASLD in ob\/ob mice by modulating lipid metabolism and inflammation in the liver. Pharmacol Res. 2025 Aug 9:219:107906. doi: 10.1016\/j.phrs.2025.107906<\/p>\n

G<\/span> onz\u00e1lez-Garc\u00eda P, Jim\u00e9nez-S\u00e1nchez L, Corral-Sarasa J, L\u00f3pez-Herrador S, Torres-Rusillo S, D\u00edaz-Casado ME, L\u00f3pez LC. The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms. Commun Med (Lond). 2025 Jul 10;5(1):286. doi: 10.1038\/s43856-025-01000-8.<\/p>\n

Z<\/span> amora-Dorta M, Laine-Men\u00e9ndez S, Abia D, Gonz\u00e1lez-Garc\u00eda P,\u00a0L\u00f3pez LC, Fern\u00e1ndez-Montes P, Calvo E, V\u00e1zquez J, Enr\u00edquez JA, Balsa E.
\nTime-resolved mitochondrial screen identifies regulatory components of oxidative metabolism. EMBO Rep. 2025 Apr 29. doi: 10.1038\/s44319-025-00459-9.<\/p>\n

P<\/span> esini A, Barriocanal-Casado E, Compagnoni GM, Hidalgo-Gutierrez A, Yanez G, Bakkali M, Chhonker YS, Kleiner G, Larrea D, Tadesse S, Lopez LC, Murry DJ, Di Fonzo A, Area-Gomez E, Quinzii CM.
\nCoenzyme Q10 deficiency disrupts lipid metabolism by altering cholesterol homeostasis in neurons. Free Radic Biol Med. 2025 Mar 1;229:441-457. doi: 10.1016\/j.freeradbiomed.2025.01.009.<\/p>\n

2023-2024<\/h2>\n

S<\/span> evilla-Lorente R, Marmol-Perez A, Gonzalez-Garcia P, Rodr\u00edguez-Miranda MLN, Riquelme-Gallego B, Aragon-Vela J, Martinez-G\u00e1lvez JM, Molina-Garcia P, Alcantara JMA, Garcia-Consuegra J, Cogliati S, Salmeron LM, Huertas JR, Lopez LC, Ruiz JR, Amaro-Gahete FJ.
\nSexual dimorphism on the acute effect of exercise in the morning vs. evening: A randomized crossover study. J Sport Health Sci. 2024 Dec 22;14:101021. doi: 10.1016\/j.jshs.2024.101021.<\/p>\n

F<\/span> abra MA, Paredes-Fuentes AJ, Torralba Carnerero M, Moreno F\u00e9rnandez de Ayala DJ, Arroyo Luque A, S\u00e1nchez Cuesta A, Staiano C, Sanchez-Pintos P, Luz Couce M, Tom\u00e1s M, Marco-Hern\u00e1ndez AV, Orellana C, Mart\u00ednez F, Rosell\u00f3 M, Caro A, Oltra Soler JS, Monfort S, S\u00e1nchez A, Rausell D, Vitoria I, Del Toro M, Garcia-Cazorla A, Julia-Palacios NA, Jou C, Yubero D, L\u00f3pez LC, Hern\u00e1ndez Camacho JD, L\u00f3pez Lluch G, Ballesteros Simarro M, Rodr\u00edguez Aguilera JC, Calvo GB, Cascajo Almenara MV, Artuch R, Santos-Oca\u00f1a C.
\nNew variants expand the neurological phenotype of COQ7 deficiency. J Inherit Metab Dis. 2024 Sep;47(5):1047-1068. doi: 10.1002\/jimd.12776.<\/p>\n

C<\/span> orral-Sarasa J, Mart\u00ednez-G\u00e1lvez JM, Gonz\u00e1lez-Garc\u00eda P, Wendling O, Jim\u00e9nez-S\u00e1nchez L, L\u00f3pez-Herrador S, Quinzii CM, D\u00edaz-Casado ME, L\u00f3pez LC.
\n4-Hydroxybenzoic acid rescues multisystemic disease and perinatal lethality in a mouse model of mitochondrial disease. Cell Rep. 2024 Apr 26:114148. doi: 10.1016\/j.celrep.2024.114148.<\/p>\n

D<\/span> \u00edaz-Casado ME, Gonz\u00e1lez-Garc\u00eda P, L\u00f3pez-Herrador S, Hidalgo-Guti\u00e9rrez A, Jim\u00e9nez-S\u00e1nchez L, Barriocanal-Casado E, Bakkali M, van de Lest CHA, Corral-Sarasa J, Zaal EA, Berkers CR, L\u00f3pez LC.
\nOral \u03b2-RA induces metabolic rewiring leading to the rescue of diet-induced obesity. Biochim Biophys Acta Mol Basis Dis. 2024 Jun 6;1870(7):167283. doi: 10.1016\/j.bbadis.2024.167283.<\/p>\n

A<\/span> rag\u00f3n-Vela J, Casuso RA, Aparisi AS, Plaza-D\u00edaz J, Rueda-Robles A, Hidalgo-Guti\u00e9rrez A, L\u00f3pez LC, Rodr\u00edguez-Carrillo A, Enriquez JA, Cogliati S, Huertas JR.<\/p>\n

Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment. J Physiol. 2024 Apr 17. doi: 10.1113\/JP285516.<\/p>\n

M<\/span> onfrini E, Pesini A, Biella F, Sobreira CFR, Emmanuele V, Brescia G, Lopez LC, Tadesse S, Hirano M, Comi GP, Quinzii CM, Di Fonzo A.
\nWhole-Exome Sequencing Study of Fibroblasts Derived From Patients With Cerebellar Ataxia Referred to Investigate CoQ10 Deficiency. Neurol Genet. 2023 Mar 14;9(2):e200058. doi: 10.1212\/NXG.0000000000200058.<\/p>\n

2022<\/h2>\n

F<\/span>lorido J, Martinez-Ruiz L, Rodriguez-Santana C, L\u00f3pez-Rodr\u00edguez A, Hidalgo-Guti\u00e9rrez A, Cottet-Rousselle C, Lamarche F, Schlattner U, Guerra-Librero A, Aranda-Mart\u00ednez P, Acu\u00f1a-Castroviejo D, L\u00f3pez LC, Escames G.
\nMelatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport. J Pineal Res. 2022 Oct;73(3):e12824. doi: 10.1111\/jpi.12824.<\/p>\n

G<\/span>onz\u00e1lez-Garc\u00eda P, D\u00edaz-Casado ME, Hidalgo-Guti\u00e9rrez A, Jim\u00e9nez-S\u00e1nchez L, Bakkali M, Barriocanal-Casado E, Escames G, Chiozzi RZ, V\u00f6llmy F, Zaal EA, Berkers CR, Heck AJR, L\u00f3pez LC.
\nThe Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency. Redox Biol. 2022 Jul 15;55:102403. doi: 10.1016\/j.redox.2022.102403.<\/p>\n

R<\/span>odr\u00edguez-Carrillo A, D’Cruz SC, Mustieles V, Su\u00e1rez B, Smagulova F, David A, Peinado F, Artacho-Cord\u00f3n F, L\u00f3pez LC, Arrebola JP, Olea N, Fern\u00e1ndez MF, Freire C.
\nExposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach. Environ Res. 2022 Aug;211:113115. doi: 10.1016\/j.envres.2022.113115.<\/p>\n

2019-2021<\/h2>\n

G<\/span>onz\u00e1lez-Garc\u00eda P, Barriocanal-Casado E, D\u00edaz-Casado ME, L\u00f3pez-Herrador S, Hidalgo-Guti\u00e9rrez A, L\u00f3pez LC.
\nAnimal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings. Antioxidants (Basel). 2021 Oct 26;10(11):1687. doi: 10.3390\/antiox10111687.<\/p>\n

H<\/span>idalgo-Guti\u00e9rrez A, Barriocanal-Casado E, D\u00edaz-Casado ME, Gonz\u00e1lez-Garc\u00eda P, Zenezini Chiozzi R, Acu\u00f1a-Castroviejo D, L\u00f3pez LC.
\n\u03b2-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight. Biomedicines. 2021 Oct 13;9(10):1457. doi: 10.3390\/biomedicines9101457.<\/p>\n

H<\/span>idalgo-Guti\u00e9rrez A, Gonz\u00e1lez-Garc\u00eda P, D\u00edaz-Casado ME, Barriocanal-Casado E, L\u00f3pez-Herrador S, Quinzii CM, L\u00f3pez LC.
\nMetabolic Targets of Coenzyme Q10 in Mitochondria. Antioxidants (Basel). 2021 Mar 26;10(4):520. doi: 10.3390\/antiox10040520.<\/p>\n

Q<\/span>uinzii CM, Lopez LC.
\nAbnormalities of hydrogen sulfide and glutathione pathways in mitochondrial dysfunction. J Adv Res. 2020 Apr 7;27:79-84. doi: 10.1016\/j.jare.2020.04.002.<\/p>\n

G<\/span>onz\u00e1lez-Garc\u00eda P, Hidalgo-Guti\u00e9rrez A, Mascaraque C, Barriocanal-Casado E, Bakkali M, Ziosi M, Abdihankyzy UB, S\u00e1nchez-Hern\u00e1ndez S, Escames G, Prokisch H, Mart\u00edn F, Quinzii CM, L\u00f3pez LC.
\nCoenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism. Hum Mol Genet. 2020 Nov 25;29(19):3296-3311. doi: 10.1093\/hmg\/ddaa214.<\/p>\n

B<\/span>arriocanal-Casado E, Hidalgo-Guti\u00e9rrez A, Raimundo N, Gonz\u00e1lez-Garc\u00eda P, Acu\u00f1a-Castroviejo D, Escames G, L\u00f3pez LC.
\nRapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease. EBioMedicine. 2019 Mar 18. pii: S2352-3964(19)30165-3. doi: 10.1016\/j.ebiom.2019.03.025.<\/p>\n

F<\/span>ernandez-Gil BI, Guerra-Librero A, Shen YQ, Florido J, Mart\u00ednez-Ruiz L, Garc\u00eda-L\u00f3pez S, Adan C, Rodr\u00edguez-Santana C, Acu\u00f1a-Castroviejo D, Qui\u00f1ones-Hinojosa A, Fern\u00e1ndez-Mart\u00ednez J, Abdel Moneim AE, L\u00f3pez LC, Rodr\u00edguez Ferrer JM, Escames G.
\nMelatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy. Oxid Med Cell Longev. 2019 Feb 28;2019:7187128. doi: 10.1155\/2019\/7187128.<\/p>\n

S<\/span>ayed RKA, Fern\u00e1ndez-Ortiz M, Diaz-Casado ME, Aranda-Mart\u00ednez P, Fern\u00e1ndez-Mart\u00ednez J, Guerra-Librero A, Escames G, L\u00f3pez LC, Alsaadawy RM, Acu\u00f1a-Castroviejo D.
\nLack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin. EJ Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz079. doi: 10.1093\/gerona\/glz079.<\/p>\n

C<\/span>asuso RA, Al-Fazazi S, Hidalgo-Gutierrez A, L\u00f3pez LC, Plaza-D\u00edaz J, Rueda-Robles A, Huertas JR.
\nHydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats. Free Radic Biol Med. 2019 Jan 24;134:304-310. doi: 10.1016\/j.freeradbiomed.2019.01.027.<\/p>\n

H<\/span>idalgo-Guti\u00e9rrez A, Barriocanal-Casado E, Bakkali M, D\u00edaz-Casado ME, S\u00e1nchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acu\u00f1a-Castroviejo D, L\u00f3pez LC.
\n\u03b2-RA reduces DMQ\/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice. EMBO Mol Med. 2019 Jan;11(1). pii: e9466. doi: 10.15252\/emmm.201809466.<\/p>\n

2018<\/h2>\n

K<\/span>leiner G, Barca E, Ziosi M, Emmanuele V, Xu Y, Hidalgo-Gutierrez A, Qiao C, Tadesse S, Area-Gomez E, Lopez LC, Quinzii CM.
\nCoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3708-3722. doi: 10.1016\/j.bbadis.2018.09.002.<\/p>\n

R<\/span>odr\u00edguez-Hidalgo M, Luna-S\u00e1nchez M, Hidalgo-Guti\u00e9rrez A, Barriocanal-Casado E, Mascaraque C, Acu\u00f1a-Castroviejo D, Rivera M, Escames G, L\u00f3pez LC.
\nReduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. Sci Rep. 2018 Sep 18;8(1):14013. doi: 10.1038\/s41598-018-32190-y.<\/p>\n

S<\/span>ayed RKA, Fern\u00e1ndez-Ortiz M, Diaz-Casado ME, Rusanova I, Rahim I, Escames G, L\u00f3pez LC, Mokhtar DM, Acu\u00f1a-Castroviejo D.
\nThe Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes. J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1330-1338. doi: 10.1093\/gerona\/gly059.<\/p>\n

S<\/span>hen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, Garc\u00eda-L\u00f3pez S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acu\u00f1a-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, L\u00f3pez LC, Escames G.
\nCombination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT\/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. J Pineal Res. 2018 Apr;64(3). doi: 10.1111\/jpi.12461.<\/p>\n

H<\/span>erebian D, L\u00f3pez LC, Distelmaier F.
\nBypassing human CoQ10 deficiency. Mol Genet Metab. 2018 Mar;123(3):289-291. doi: 10.1016\/j.ymgme.2017.12.008. Epub 2017<\/p>\n

D<\/span>\u00edaz-Casado ME, Rusanova I, Aranda P, Fern\u00e1ndez-Ortiz M, Sayed RKA, Fern\u00e1ndez-Gil BI, Hidalgo-Guti\u00e9rrez A, Escames G, L\u00f3pez LC, Acu\u00f1a-Castroviejo D.
\nIn Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy. Zebrafish. 2018 Feb;15(1):15-26. doi: 10.1089\/zeb.2017.1479.<\/p>\n

2017<\/h2>\n

L<\/span>\u00f3pez A, Ortiz F, Doerrier C, Venegas C, Fern\u00e1ndez-Ortiz M, Aranda P, D\u00edaz-Casado ME, Fern\u00e1ndez-Gil B, Barriocanal-Casado E, Escames G, L\u00f3pez LC, Acu\u00f1a-Castroviejo D.
\nMitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases. PLoS One. 2017 Aug 11;12(8):e0183090.<\/p>\n

Q<\/span>uinzii CM, Luna-Sanchez M, Ziosi M, Hidalgo-Gutierrez A, Kleiner G, Lopez LC.
\nThe Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency. Front Physiol. 2017 Jul 25;8:525.<\/p>\n

A<\/span>cu\u00f1a-Castroviejo D, Rahim I, Acu\u00f1a-Fern\u00e1ndez C, Fern\u00e1ndez-Ortiz M, Solera-Mar\u00edn J, Sayed RKA, D\u00edaz-Casado ME, Rusanova I, L\u00f3pez LC, Escames G.
\nMelatonin, clock genes and mitochondria in sepsis. Cell Mol Life Sci. 2017 Nov;74(21):3965-3987.<\/p>\n

H<\/span>uertas JR, Al Fazazi S, Hidalgo-Gutierrez A, L\u00f3pez LC, Casuso RA.
\nAntioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly. Redox Biol. 2017 Oct;13:477-481<\/p>\n

H<\/span>erebian D, Seibt A, Smits SHJ, B\u00fcnning G, Freyer C, Prokisch H, Karall D, Wredenberg A, Wedell A, L\u00f3pez LC, Mayatepek E, Distelmaier F.
\nDetection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics. Mol Genet Metab. 2017 Jul;121(3):216-223.<\/p>\n

M<\/span>endivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, Acu\u00f1a-Castroviejo D, L\u00f3pez LC, Velez-Pardo C, Jimenez-Del-Rio M, Ferrer JM, Escames G.
\nMelatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function. J Pineal Res. 2017 Sep;63(2). doi: 10.1111\/jpi.12415.<\/p>\n

F<\/span>ern\u00e1ndez-Gil B, Moneim AE, Ortiz F, Shen YQ, Soto-Mercado V, Mendivil-Perez M, Guerra-Librero A, Acu\u00f1a-Castroviejo D, Molina-Navarro MM, Garc\u00eda-Verdugo JM, Sayed RK, Florido J, Luna JD, L\u00f3pez LC, Escames G.
\nMelatonin protects rats from radiotherapy-induced small intestine toxicity. PLoS One. 2017 Apr 12;12(4):e0174474.<\/p>\n

R<\/span>ahim I, Djerdjouri B, Sayed RK, Fern\u00e1ndez-Ortiz M, Fern\u00e1ndez-Gil B, Hidalgo-Guti\u00e9rrez A, L\u00f3pez LC, Escames G, Reiter RJ, Acu\u00f1a-Castroviejo D.
\nMelatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Aug;63(1). doi: 10.1111\/jpi.12410.<\/p>\n

F<\/span>ern\u00e1ndez-Mosquera L, Diogo CV, Yambire KF, Santos GL, Luna S\u00e1nchez M, B\u00e9nit P, Rustin P, Lopez LC, Milosevic I, Raimundo N.
\nAcute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis. Sci Rep. 2017 Mar 27;7:45076. doi: 10.1038\/srep45076.<\/p>\n

L<\/span>una-S\u00e1nchez M, Hidalgo-Guti\u00e9rrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila \u00c1, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acu\u00f1a-Castroviejo D, L\u00f3pez LC.
\nCoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome. EMBO Mol Med. 2017 Nov 17; 9(1):78-95. pii: e201606345. doi: 10.15252\/emmm.201606345.<\/p>\n

2016-2015<\/h2>\n

B<\/span>arriocanal-Casado E, Cueto-Ure\u00f1a C, Benabdellah K, Guti\u00e9rrez-Guerrero A, Cobo M, Hidalgo-Guti\u00e9rrez A, Rodr\u00edguez-Sevilla JJ, Mart\u00edn F, L\u00f3pez LC.
\nGene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice. PLoS One. 2016 Jun 24;11(6):e0158344. doi: 10.1371\/journal.pone.0158344.<\/p>\n

V<\/span>olt H, Garc\u00eda JA, Doerrier C, D\u00edaz-Casado ME, Guerra-Librero A, L\u00f3pez LC, Escames G, Tresguerres JA, Acu\u00f1a-Castroviejo D.
\nSame molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res. 2015 Dec 17. doi: 10.1111\/jpi.12303.<\/p>\n

G<\/span>arc\u00eda JA, Volt H, Venegas C, Doerrier C, Escames G, L\u00f3pez LC, Acu\u00f1a-Castroviejo D.
\nDisruption of the NF-\u03baB\/NLRP3 connection by melatonin requires retinoid-related orphan receptor-\u03b1 and blocks the septic response in mice. FASEB J. 2015 Sep;29(9):3863-75. doi: 10.1096\/fj.15-273656.<\/p>\n

G<\/span>arcia-Diaz B, Barca E, Balreira A, Lopez LC, Tadesse S, Krishna S, Naini A, Mariotti C, Castellotti B, Quinzii CM.
\nLack of aprataxin impairs mitochondrial functions via down-regulation of the APE1\/ NRF1\/NRF2 pathway. Hum Mol Genet. 2015 Aug 15;24(16):4516-29. doi: 10.1093\/hmg\/ddv183.<\/p>\n

L<\/span>una\u2010S\u00e1nchez M, D\u00edaz\u2010Casado E, Barca E, Tejada MA, Montilla\u2010Garc\u00eda A, Cobos EJ, Escames G, Acu\u00f1a\u2010Castroviejo D, Quinzii CM, L\u00f3pez LC.
\nThe clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. EMBO Mol Med. 2015 Mar 23;7(5):670-87. doi: 10.15252\/emmm.201404632.<\/p>\n

O<\/span>rtiz F, Acu\u00f1a-Castroviejo D, Doerrier C, Dayoub JC, L\u00f3pez LC, Venegas C, Garc\u00eda JA, L\u00f3pez A, Volt H, Luna-S\u00e1nchez M, Escames G.
\nMelatonin blunts the mitochondrial\/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res. 2015 Jan;58(1):34-49. doi: 10.1111\/jpi.12191. Epub 2014 Dec 4. PMID: 25388914<\/p>\n

2014-2013<\/h2>\n

L<\/span>ohman DC, Forouhar F, Beebe ET, Stefely MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-S\u00e1nchez M, Jochem A, Lew S, Seetharaman J, Xiao R, Wang H, Westphall MS, Wrobel RL, Everett JK, Mitchell JC, L\u00f3pez LC, Coon JJ, Tong L, Pagliarini DJ.
\nCOQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proc Natl Acad Sci U S A. 2014 Oct 22. pii: 201413128. [Epub ahead of print] PMID: 25339443<\/p>\n

L<\/span>\u00f3pez LC, Luna-S\u00e1nchez M, Garc\u00eda-Corzo L, Quinzii CM, Hirano M.
\nPathomechanisms in coenzyme q10-deficient human fibroblasts. Mol Syndromol. 2014 Jul;5(3-4):163-9. doi: 10.1159\/000360494. PubMed PMID: 25126049; PubMed Central PMCID: PMC4112524.<\/p>\n

G<\/span>arone C, Garcia-Diaz B, Emmanuele V, Lopez LC, Tadesse S, Akman HO, Tanji K, Quinzii CM, Hirano M.
\nDeoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency. EMBO Mol Med. 2014 Jun 26;6(8):1016-27. doi:10.15252\/emmm.201404092. PubMed PMID: 24968719; PubMed Central PMCID: PMC4154130.<\/p>\n

L<\/span>ima-Cabello E, D\u00edaz-Casado ME, Guerrero JA, Otalora BB, Escames G, L\u00f3pez LC, Reiter RJ, Acu\u00f1a-Castroviejo D.
\nA review of the melatonin functions in zebrafish physiology. J Pineal Res. 2014 Aug;57(1):1-9. doi: 10.1111\/jpi.12149. Epub 2014Jul 3. PubMed PMID: 24920150.<\/p>\n

G<\/span>arc\u00eda-Corzo L, Luna-S\u00e1nchez M, Doerrier C, Ortiz F, Escames G, Acu\u00f1a-Castroviejo D, L\u00f3pez LC.
\nUbiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Feb24;1842(7):893-901. doi: 10.1016\/j.bbadis.2014.02.008. [Epub ahead of print]PubMed PMID: 24576561.<\/p>\n

A<\/span>cu\u00f1a-Castroviejo D, Escames G, Venegas C, D\u00edaz-Casado ME, Lima-Cabello E, L\u00f3pez LC, Rosales-Corral S, Tan DX, Reiter RJ.
\nExtrapineal melatonin: sources,regulation, and potential functions. Cell Mol Life Sci. 2014 Feb 20. [Epub ahead of print] PubMed PMID: 24554058.<\/p>\n

O<\/span>rtiz F, Garc\u00eda JA, Acu\u00f1a-Castroviejo D, Doerrier C, L\u00f3pez A, Venegas C, Volt H, Luna-S\u00e1nchez M, L\u00f3pez LC, Escames G.
\nThe beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. J Pineal Res. 2014 Jan;56(1):71-81. doi: 10.1111\/jpi.12099. Epub 2013 Oct 21. PubMed PMID: 24117944.<\/p>\n

L<\/span>\u00f3pez LC, Cabrera-Vique C, Venegas C, Garc\u00eda-Corzo L, Luna-S\u00e1nchez M, Acu\u00f1a-Castroviejo D, Escames G.
\nArgan oil-contained antioxidants for human mitochondria. Nat Prod Commun. 2013 Jan;8(1):47-50. Review. PubMed PMID: 23472457.<\/p>\n

R<\/span>omero-Moya D, Bueno C, Montes R, Navarro-Montero O, Iborra FJ, L\u00f3pez LC, Martin M, Menendez P.
\nCord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function. Haematologica. 2013 Jul;98(7):1022-9. doi: 10.3324\/haematol.2012.079244. Epub 2013 Jan 24. PubMed PMID: 23349299; PubMed Central PMCID: PMC3696604.<\/p>\n

G<\/span>arc\u00eda-Corzo L, Luna-S\u00e1nchez M, Doerrier C, Garc\u00eda JA, Guar\u00e1s A, Ac\u00edn-P\u00e9rez R, Bullejos-Peregr\u00edn J, L\u00f3pez A, Escames G, Enr\u00edquez JA, Acu\u00f1a-Castroviejo D, L\u00f3pez LC.
\nDysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Hum Mol Genet. 2013 Mar 15;22(6):1233-48. doi:10.1093\/hmg\/dds530. Epub 2012 Dec 18. PubMed PMID: 23255162.<\/p>\n

V<\/span>enegas C, Garc\u00eda JA, Doerrier C, Volt H, Escames G, L\u00f3pez LC, Reiter RJ, Acu\u00f1a-Castroviejo D.
\nAnalysis of the daily changes of melatonin receptors in the rat liver. J Pineal Res. 2013 Apr;54(3):313-21. doi: 10.1111\/jpi.12019. Epub 2012 Oct 30. PubMed PMID: 23110416.<\/p>\n

2012-2011<\/h2>\n

E<\/span>mmanuele V, L\u00f3pez LC, Berardo A, Naini A, Tadesse S, Wen B, D’Agostino E, Solomon M, DiMauro S, Quinzii C, Hirano M.
\nHeterogeneity of coenzyme Q10 deficiency: patient study and literature review. Arch Neurol. 2012 Aug;69(8):978-83. doi: 10.1001\/archneurol.2012.206. Review. Erratum in: Arch Neurol. 2012 Jul;69(7):886. L\u00f3pez, Luis [corrected to L\u00f3pez, Luis C]. PubMedPMID: 22490322; PubMed Central PMCID: PMC3639472.<\/p>\n

M<\/span>art\u00ed R, L\u00f3pez LC, Hirano M.
\nAssessment of thymidine phosphorylase function: measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity. Methods Mol Biol. 2012;837:121-33. doi: 10.1007\/978-1-61779-504-6_8. PubMed PMID: 22215544.<\/p>\n

V<\/span>enegas C, Cabrera-Vique C, Garc\u00eda-Corzo L, Escames G, Acu\u00f1a-Castroviejo D, L\u00f3pez LC.
\nDetermination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils. J Agric Food Chem. 2011 Nov 23;59(22):12102-8. doi: 10.1021\/jf203428t. Epub 2011 Oct 31. PubMed PMID: 22007968.<\/p>\n

V<\/span>enegas C, Garc\u00eda JA, Escames G, Ortiz F, L\u00f3pez A, Doerrier C, Garc\u00eda-Corzo L, L\u00f3pez LC, Reiter RJ, Acu\u00f1a-Castroviejo D.
\nExtrapineal melatonin: analysis of its subcellular distribution and daily fluctuations. J Pineal Res. 2012 Mar;52(2):217-27. doi: 10.1111\/j.1600-079X.2011.00931.x. Epub 2011 Sep 2. PubMed PMID: 21884551.<\/p>\n

E<\/span>scames G, L\u00f3pez LC, Garc\u00eda JA, Garc\u00eda-Corzo L, Ortiz F, Acu\u00f1a-Castroviejo D.
\nMitochondrial DNA and inflammatory diseases. Hum Genet. 2012 Feb;131(2):161-73. doi: 10.1007\/s00439-011-1057-y. Epub 2011 Jul 7. Review. PubMed PMID: 21735170.<\/p>\n

A<\/span>cu\u00f1a-Castroviejo D, Carretero M, Doerrier C, L\u00f3pez LC, Garc\u00eda-Corzo L, Tresguerres JA, Escames G.
\nMelatonin protects lung mitochondria from aging. Age (Dordr). 2012 Jun;34(3):681-92. doi: 10.1007\/s11357-011-9267-8. Epub 2011 May 26. PubMed PMID: 21614449; PubMed Central PMCID: PMC3337938.<\/p>\n

D<\/span>ayoub JC, Ortiz F, L\u00f3pez LC, Venegas C, Del Pino-Zumaquero A, Roda O, S\u00e1nchez-Montesinos I, Acu\u00f1a-Castroviejo D, Escames G.
\nSynergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide. J Pineal Res. 2011 Oct;51(3):324-30. doi: 10.1111\/j.1600-079X.2011.00892.x. Epub 2011 May 17. PubMed PMID: 21585521.<\/p>\n

C<\/span>hahbouni M, Escames G, L\u00f3pez LC, Sevilla B, Doerrier C, Mu\u00f1oz-Hoyos A, Molina-Carballo A, Acu\u00f1a-Castroviejo D.
\nMelatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy. Clin Biochem. 2011 Jul;44(10-11):853-8. doi: 10.1016\/j.clinbiochem.2011.04.001. Epub 2011 Apr 15. PubMed PMID: 21515247.<\/p>\n

A<\/span>cu\u00f1a-Castroviejo D, Tapias V, L\u00f3pez LC, Doerrier C, Camacho E, Carri\u00f3n MD, Mora F, Espinosa A, Escames G.
\nProtective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Brain Res Bull. 2011 May 30;85(3-4):133-40. doi: 10.1016\/j.brainresbull.2011.03.008. Epub 2011 Mar 17. PubMed PMID: 21419832.<\/p>\n

E<\/span>scames G, L\u00f3pez A, Garc\u00eda JA, Garc\u00eda L, Acu\u00f1a-Castroviejo D, Garc\u00eda JJ, L\u00f3pez LC.
\nThe role of mitochondria in brain aging and the effects of melatonin. Curr Neuropharmacol. 2010 Sep;8(3):182-93. doi: 10.2174\/157015910792246245. PubMed PMID: 21358969; PubMed Central PMCID: PMC3001212.<\/p>\n

A<\/span>cu\u00f1a Castroviejo D, L\u00f3pez LC, Escames G, L\u00f3pez A, Garc\u00eda JA, Reiter RJ.
\nMelatonin-mitochondria interplay in health and disease. Curr Top Med Chem. 2011;11(2):221-40. Review. PubMed PMID: 21244359.<\/p>\n

C<\/span>astroviejo DA, L\u00f3pez LC, Escames G, L\u00f3pez A, Garc\u00eda JA, Reiter RJ.
\nMelatonin-mitochondria Interplay in Health and Disease. Curr Top Med Chem. 2010 Dec 28. [Epub ahead of print] PubMed PMID: 21192780.<\/p>\n

2010-2008<\/h2>\n

L<\/span>\u00f3pez LC, Quinzii CM, Area E, Naini A, Rahman S, Schuelke M, Salviati L, Dimauro S, Hirano M.
\nTreatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects. PLoS One. 2010 Jul 30;5(7):e11897. doi: 10.1371\/journal.pone.0011897. PubMed PMID: 20689595; PubMed Central PMCID: PMC2912846.<\/p>\n

Q<\/span>uinzii CM, L\u00f3pez LC, Gilkerson RW, Dorado B, Coku J, Naini AB, Lagier-Tourenne C, Schuelke M, Salviati L, Carrozzo R, Santorelli F, Rahman S, Tazir M, Koenig M, DiMauro S, Hirano M.
\nReactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency. FASEB J. 2010 Oct;24(10):3733-43. doi: 10.1096\/fj.09-152728. Epub 2010 May 21. PubMed PMID: 20495179; PubMed Central PMCID: PMC2996902.<\/p>\n

C<\/span>hahbouni M, Escames G, Venegas C, Sevilla B, Garc\u00eda JA, L\u00f3pez LC, Mu\u00f1oz-Hoyos A, Molina-Carballo A, Acu\u00f1a-Castroviejo D.
\nMelatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative\/oxidative stress in patients suffering from Duchenne muscular dystrophy. J Pineal Res. 2010 Apr;48(3):282-9. doi: 10.1111\/j.1600-079X.2010.00752.x. Epub 2010 Mar 4. PubMed PMID: 20210854.<\/p>\n

C<\/span>arretero M, Escames G, L\u00f3pez LC, Venegas C, Dayoub JC, Garc\u00eda L, Acu\u00f1a-Castroviejo D.
\nLong-term melatonin administration protects brain mitochondria from aging. J Pineal Res. 2009 Sep;47(2):192-200. doi: 10.1111\/j.1600-079X.2009.00700.x. Epub 2009 Jul 1. PubMed PMID: 19573039.<\/p>\n

T<\/span>apias V, Escames G, L\u00f3pez LC, L\u00f3pez A, Camacho E, Carri\u00f3n MD, Entrena A, Gallo MA, Espinosa A, Acu\u00f1a-Castroviejo D.
\nMelatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. J Neurosci Res. 2009 Oct;87(13):3002-10. doi:10.1002\/jnr.22123. PubMed PMID: 19437546.<\/p>\n

D<\/span>uncan AJ, Bitner-Glindzicz M, Meunier B, Costello H, Hargreaves IP, L\u00f3pez LC, Hirano M, Quinzii CM, Sadowski MI, Hardy J, Singleton A, Clayton PT, Rahman S.
\nA nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease.Am J Hum Genet. 2009 May;84(5):558-66. doi: 10.1016\/j.ajhg.2009.03.018. Epub 2009 Apr 16. PubMed PMID: 19375058; PubMed Central PMCID: PMC2681001.<\/p>\n

L<\/span>iang WC, Ohkuma A, Hayashi YK, L\u00f3pez LC, Hirano M, Nonaka I, Noguchi S, Chen LH, Jong YJ, Nishino I.
\nETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Neuromuscul Disord. 2009 Mar;19(3):212-6. doi: 10.1016\/j.nmd.2009.01.008. Epub 2009 Feb 26. PubMed PMID: 19249206.<\/p>\n

O<\/span>hkuma A, Noguchi S, Sugie H, Malicdan MC, Fukuda T, Shimazu K, L\u00f3pez LC, Hirano M, Hayashi YK, Nonaka I, Nishino I.
\nClinical and genetic analysis of lipid storage myopathies. Muscle Nerve. 2009 Mar;39(3):333-42. doi: 10.1002\/mus.21167. PubMed PMID: 19208393.<\/p>\n

Q<\/span>uinzii CM, L\u00f3pez LC, Naini A, DiMauro S, Hirano M.
\nHuman CoQ10 deficiencies. Biofactors. 2008;32(1-4):113-8. PubMed PMID: 19096106; PubMed Central PMCID: PMC3625975.<\/p>\n

L<\/span>\u00f3pez A, Garc\u00eda JA, Escames G, Venegas C, Ortiz F, L\u00f3pez LC, Acu\u00f1a-Castroviejo D.
\nMelatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production.J Pineal Res. 2009 Mar;46(2):188-98. doi: 10.1111\/j.1600-079X.2008.00647.x. Epub 2008 Nov 19. PubMed PMID: 19054298.<\/p>\n

L<\/span>\u00f3pez LC, Akman HO, Garc\u00eda-Cazorla A, Dorado B, Mart\u00ed R, Nishino I, Tadesse S, Pizzorno G, Shungu D, Bonilla E, Tanji K, Hirano M.
\nUnbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice. Hum Mol Genet. 2009 Feb 15;18(4):714-22. doi: 10.1093\/hmg\/ddn401. Epub 2008 Nov 21. PubMed PMID: 19028666; PubMed Central PMCID: PMC2638828.<\/p>\n

R<\/span>odr\u00edguez MI, Escames G, L\u00f3pez LC, L\u00f3pez A, Garc\u00eda JA, Ortiz F, S\u00e1nchez V, Romeu M, Acu\u00f1a-Castroviejo D.
\nImproved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice. Exp Gerontol. 2008 Aug;43(8):749-56. doi: 10.1016\/j.exger.2008.04.003. Epub 2008 Apr 6. PubMed PMID: 18485648.<\/p>\n

A<\/span>kman HO, Dorado B, L\u00f3pez LC, Garc\u00eda-Cazorla A, Vil\u00e0 MR, Tanabe LM, Dauer WT, Bonilla E, Tanji K, Hirano M.
\nThymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance. Hum Mol Genet. 2008 Aug 15;17(16):2433-40. doi: 10.1093\/hmg\/ddn143. Epub 2008 May 8. PubMed PMID: 18467430; PubMed Central PMCID: PMC3115590.<\/p>\n

L<\/span>agier-Tourenne C, Tazir M, L\u00f3pez LC, Quinzii CM, Assoum M, Drouot N, Busso C, Makri S, Ali-Pacha L, Benhassine T, Anheim M, Lynch DR, Thibault C, Plewniak F, Bianchetti L, Tranchant C, Poch O, DiMauro S, Mandel JL, Barros MH, Hirano M, Koenig M.
\nADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet. 2008 Mar;82(3):661-72. doi: 10.1016\/j.ajhg.2007.12.024. PubMed PMID: 18319074; PubMed Central PMCID: PMC2427193.<\/p>\n

Q<\/span>uinzii CM, L\u00f3pez LC, Von-Moltke J, Naini A, Krishna S, Schuelke M, Salviati L, Navas P, DiMauro S, Hirano M.
\nRespiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency. FASEB J. 2008 Jun;22(6):1874-85. doi: 10.1096\/fj.07-100149. Epub 2008 Jan 29. PubMed PMID: 18230681; PubMed Central PMCID: PMC2731482.<\/p>\n

2007-2004<\/h2>\n

R<\/span>odriguez MI, Escames G, L\u00f3pez LC, Garc\u00eda JA, Ortiz F, L\u00f3pez A, Acu\u00f1a-Castroviejo D.
\nMelatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice. J Endocrinol. 2007 Sep;194(3):637-43. PubMed PMID: 17761903.<\/p>\n

G<\/span>arc\u00eda-Navarro A, Gonz\u00e1lez-Puga C, Escames G, L\u00f3pez LC, L\u00f3pez A, L\u00f3pez-Cantarero M, Camacho E, Espinosa A, Gallo MA, Acu\u00f1a-Castroviejo D.
\nCellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. J Pineal Res. 2007 Sep;43(2):195-205. PubMed PMID:17645698.<\/p>\n

V<\/span>alentino ML, Mart\u00ed R, Tadesse S, L\u00f3pez LC, Manes JL, Lyzak J, Hahn A, Carelli V, Hirano M.
\nThymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). FEBS Lett. 2007 Jul 24;581(18):3410-4. Epub 2007 Jun 27. PubMed PMID: 17612528; PubMed Central PMCID: PMC1986782.<\/p>\n

E<\/span>scames G, L\u00f3pez LC, Ortiz F, L\u00f3pez A, Garc\u00eda JA, Ros E, Acu\u00f1a-Castroviejo D.
\nAttenuation of cardiac mitochondrial dysfunction by melatonin in septic mice. FEBS J. 2007 Apr;274(8):2135-47. Epub 2007 Mar 20. PubMed PMID: 17371545.<\/p>\n

R<\/span>odr\u00edguez MI, Escames G, L\u00f3pez LC, L\u00f3pez A, Garc\u00eda JA, Ortiz F, Acu\u00f1a-Castroviejo D.
\nChronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice. J Pineal Res. 2007 Apr;42(3):272-9. PubMed PMID: 17349026.<\/p>\n

L<\/span>\u00f3pez LC, Schuelke M, Quinzii CM, Kanki T, Rodenburg RJ, Naini A, Dimauro S, Hirano M.
\nLeigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet. 2006 Dec;79(6):1125-9. Epub 2006 Oct 27. PubMed PMID: 17186472; PubMed Central PMCID: PMC1698707.<\/p>\n

R<\/span>odr\u00edguez MI, Carretero M, Escames G, L\u00f3pez LC, Maldonado MD, Tan DX, Reiter RJ, Acu\u00f1a-Castroviejo D.
\nChronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice. Free Radic Res. 2007 Jan;41(1):15-24. PubMed PMID: 17164175.<\/p>\n

L<\/span>\u00f3pez LC, Escames G, Ortiz F, Ros E, Acu\u00f1a-Castroviejo D.
\nMelatonin restores the mitochondrial production of ATP in septic mice. Neuro Endocrinol Lett. 2006 Oct;27(5):623-30. PubMed PMID: 17159820.<\/p>\n

A<\/span>cuna-Castroviejo D, Escames G, Rodriguez MI, Lopez LC.
\nMelatonin role in the mitochondrial function. Front Biosci. 2007 Jan 1;12:947-63. Review. PubMed PMID: 17127351.<\/p>\n

E<\/span>scames G, L\u00f3pez LC, Ortiz F, Ros E, Acu\u00f1a-Castroviejo D.
\nAge-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. Exp Gerontol. 2006 Nov;41(11):1165-73. Epub 2006 Oct 17. PubMed PMID: 17049787.<\/p>\n

E<\/span>scames G, Acu\u00f1a-Castroviejo D, L\u00f3pez LC, Tan DX, Maldonado MD, S\u00e1nchez-Hidalgo M, Le\u00f3n J, Reiter RJ.
\nPharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence. J Pharm Pharmacol. 2006 Sep;58(9):1153-65. Review. PubMed PMID: 16945173.<\/p>\n

L<\/span>e\u00f3n J, Escames G, Rodr\u00edguez MI, L\u00f3pez LC, Tapias V, Entrena A, Camacho E, Carri\u00f3n MD, Gallo MA, Espinosa A, Tan DX, Reiter RJ, Acu\u00f1a-Castroviejo D. Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin. J Neurochem. 2006 Sep;98(6):2023-33. PubMed PMID: 16945113.<\/p>\n

E<\/span>scames G, L\u00f3pez LC, Tapias V, Utrilla P, Reiter RJ, Hitos AB, Le\u00f3n J, Rodr\u00edguez MI, Acu\u00f1a-Castroviejo D.
\nMelatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice. J Pineal Res. 2006 Jan;40(1):71-8. PubMed PMID: 16313501.<\/p>\n

L<\/span>\u00f3pez LC, Escames G, Tapias V, Utrilla P, Le\u00f3n J, Acu\u00f1a-Castroviejo D.
\nIdentification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin. Int J Biochem Cell Biol. 2006 Feb;38(2):267-78. Epub 2005 Sep 30. PubMed PMID: 16223598.<\/p>\n

A<\/span>cu\u00f1a-Castroviejo D, Escames G, L\u00f3pez LC, Hitos AB, Le\u00f3n J.
\nMelatonin and nitric oxide: two required antagonists for mitochondrial homeostasis. Endocrine. 2005 Jul;27(2):159-68. Review. PubMed PMID: 16217129.<\/p>\n

E<\/span>scames G, Le\u00f3n J, L\u00f3pez LC, Acu\u00f1a-Castroviejo D.
\nMechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum. J Neuroendocrinol. 2004 Nov;16(11):929-35. PubMed PMID: 15584934.<\/p>\n","protected":false},"excerpt":{"rendered":"

2025-2026 istelmaier F, Corral-Sarasa J, Jim\u00e9nez-S\u00e1nchez L, D\u00edaz-Casado ME, Rohmann M, Seibt A, Herebian D, Smits SHJ, M\u00fcnch J, Mayatepek E, Breitkreutz J, Husain RA,…<\/p>\n

Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/pages\/2497"}],"collection":[{"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/comments?post=2497"}],"version-history":[{"count":57,"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/pages\/2497\/revisions"}],"predecessor-version":[{"id":3190,"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/pages\/2497\/revisions\/3190"}],"wp:attachment":[{"href":"https:\/\/wpd.ugr.es\/~luisca\/wp-json\/wp\/v2\/media?parent=2497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}