{"id":590,"date":"2022-01-22T09:07:53","date_gmt":"2022-01-22T09:07:53","guid":{"rendered":"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590"},"modified":"2022-03-21T17:07:12","modified_gmt":"2022-03-21T17:07:12","slug":"test1","status":"publish","type":"page","link":"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590","title":{"rendered":"Metallized ds-DNA"},"content":{"rendered":"\n<h2 class=\"has-vivid-cyan-blue-color has-text-color wp-block-heading\" id=\"metallized-double-stranded-dna-molecules\">Metallized double-stranded DNA molecules<\/h2>\n\n\n\n<p class=\"has-black-color has-text-color\">We have developed a novel strategy to form metal-DNA hybrids. It is based on the use of DNA sequences in which all purine bases (adenine and guanine) are replaced by their 7-deazapurine analogues (7-deazaadenine and 7-deazaguanine). These deaza-DNA molecules retain the natural ability to self-assemble through Watson-Crick-Franklin base pairing, but surprisingly, they can also be transformed into metal-DNA by the addition of specific metal ions, while retaining their original structure. Metalation occurs at Watson-Crick-Franklin positions, in a rational and controlled manner, where metal ions replace the original hydrogen bonds and originate &#8220;metal-modified base pairs&#8221;. Thus, metal-DNA systems of different sizes and\/or conformation can be obtained through the correct programming of the oligonucleotide sequence, and that contain metal ions that run along the central axis of the double-strand. As a result, metal-DNA hybrids can develop new physicochemical properties implemented by metal ions.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"436\" src=\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-1024x436.png\" alt=\"\" class=\"wp-image-804\" srcset=\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-1024x436.png 1024w, https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-300x128.png 300w, https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-768x327.png 768w, https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-1536x654.png 1536w, https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3.png 1971w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>Schematic representation for the formation of Ag-DNA molecules where silver ions are placed inside the double helix and form silver-modified base pairs<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Metallized double-stranded DNA molecules We have developed a novel strategy to form metal-DNA hybrids. It is based on the use of DNA sequences in which all purine bases (adenine and guanine) are replaced by their 7-deazapurine analogues (7-deazaadenine and 7-deazaguanine). These deaza-DNA molecules retain the natural ability to self-assemble through Watson-Crick-Franklin base pairing, but surprisingly, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-590","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Metallized ds-DNA - Metal_DNA Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Metallized ds-DNA - Metal_DNA Lab\" \/>\n<meta property=\"og:description\" content=\"Metallized double-stranded DNA molecules We have developed a novel strategy to form metal-DNA hybrids. It is based on the use of DNA sequences in which all purine bases (adenine and guanine) are replaced by their 7-deazapurine analogues (7-deazaadenine and 7-deazaguanine). These deaza-DNA molecules retain the natural ability to self-assemble through Watson-Crick-Franklin base pairing, but surprisingly, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590\" \/>\n<meta property=\"og:site_name\" content=\"Metal_DNA Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2022-03-21T17:07:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-1024x436.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Galindo_Lab\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590\",\"url\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590\",\"name\":\"Metallized ds-DNA - Metal_DNA Lab\",\"isPartOf\":{\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590#primaryimage\"},\"image\":{\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590#primaryimage\"},\"thumbnailUrl\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3-1024x436.png\",\"datePublished\":\"2022-01-22T09:07:53+00:00\",\"dateModified\":\"2022-03-21T17:07:12+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590#primaryimage\",\"url\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3.png\",\"contentUrl\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/wp-content\/uploads\/2022\/03\/image-3.png\",\"width\":1971,\"height\":839},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/?page_id=590#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Metallized ds-DNA\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/#website\",\"url\":\"https:\/\/wpd.ugr.es\/~magalindo\/wordpress\/\",\"name\":\"Metal_DNA Lab\",\"description\":\"Miguel A. 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