{"id":434,"date":"2020-10-05T17:39:19","date_gmt":"2020-10-05T17:39:19","guid":{"rendered":"https:\/\/wpd.ugr.es\/~mariocano\/?page_id=434"},"modified":"2026-02-07T08:11:11","modified_gmt":"2026-02-07T08:11:11","slug":"covid-19","status":"publish","type":"page","link":"https:\/\/wpd.ugr.es\/~mariocano\/covid-19\/","title":{"rendered":"COVID-19"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"434\" class=\"elementor elementor-434\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1efb1ece elementor-section-items-top elementor-section-height-min-height elementor-section-boxed elementor-section-height-default\" data-id=\"1efb1ece\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-553cc796\" data-id=\"553cc796\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c9ffd02 animated-slow elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"7c9ffd02\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-large\">COVID-19<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-207e9222 animated-slow elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"207e9222\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;,&quot;_animation_delay&quot;:100}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">ResearcH<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69464122 animated-slow elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"69464122\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0df715 animated-slow elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"a0df715\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon elementor-animation-grow-rotate\" href=\"#More\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 510.974 510.974\" width=\"512\"><g><path d=\"m492.361 251.124c-6.043-1.184-12.182.054-17.292 3.487-4.232 2.844-7.338 6.913-8.953 11.659l-26.259-11.467c.054-1.797.081-3.568.081-5.293 0-15.439-1.933-30.769-5.747-45.62l11.779-7.99c7.466 6.539 18.317 8.494 27.817 4.367 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11.337-11.336z\"><\/path><path d=\"m159.94 354.598c14.955 0 27.122-12.167 27.122-27.122s-12.167-27.122-27.122-27.122-27.122 12.167-27.122 27.122 12.167 27.122 27.122 27.122zm0-39.244c6.685 0 12.122 5.438 12.122 12.122s-5.438 12.122-12.122 12.122-12.122-5.438-12.122-12.122 5.438-12.122 12.122-12.122z\"><\/path><path d=\"m312.663 233.613c0-4.142-3.357-7.5-7.5-7.5h-6.63c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5h6.63c4.143 0 7.5-3.358 7.5-7.5z\"><\/path><path d=\"m210.025 372.213h6.812c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5h-6.812c-4.143 0-7.5 3.358-7.5 7.5s3.358 7.5 7.5 7.5z\"><\/path><path d=\"m146.88 262.991c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5h-6.562c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5z\"><\/path><path d=\"m280.087 131.774c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5h-9.132c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5z\"><\/path><path d=\"m329.979 332.797c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5h10.084c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5z\"><\/path><\/g><\/svg>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-196496b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"196496b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7de0af5 animated-slow elementor-invisible\" data-id=\"7de0af5\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-367488a elementor-widget elementor-widget-heading\" data-id=\"367488a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-large\">Our Research Project<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cebc7b0 elementor-widget elementor-widget-text-editor\" data-id=\"cebc7b0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p>We are currently undergoing a Research Project called: Design of mimetic proteins that block the fusion of SARS-Cov-2 with the host cell.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abb744a elementor-align-left elementor-mobile-align-center elementor-invisible elementor-widget elementor-widget-button\" data-id=\"abb744a\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#CovidProject\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">learn more<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-17d1629\" data-id=\"17d1629\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f707050 elementor-widget elementor-widget-menu-anchor\" data-id=\"f707050\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"More\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5595f6d animated-slow elementor-invisible elementor-widget elementor-widget-htmega-imagemarker-addons\" data-id=\"5595f6d\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"htmega-imagemarker-addons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t            <div class=\"htmega-marker-wrapper htmega-marker-style-4\" >\r\n\r\n                                        <div class=\"htmega_image_pointer elementor-repeater-item-c17cef5\">\r\n                            <div class=\"htmega_pointer_box\">\r\n                                <h4>S1<\/h4><p>S1 subunit contains a receptor binding domain (RBD), which is responsible for recognizing and binding with the cell surface receptor. <\/p>                            <\/div>\r\n                        <\/div>\r\n                                            <div class=\"htmega_image_pointer elementor-repeater-item-ee368f2\">\r\n                            <div class=\"htmega_pointer_box\">\r\n                                <h4>S2<\/h4><p>S2 subunit contains other basic elements needed for the membrane fusion.<\/p>                            <\/div>\r\n                        <\/div>\r\n                                            <div class=\"htmega_image_pointer elementor-repeater-item-feb90c7\">\r\n                            <div class=\"htmega_pointer_box\">\r\n                                <h4>Membrane<\/h4><p>Enveloped viruses contain a nucleocapsid surrounded by a lipid bilayer which accommodates the viral membrane proteins.<\/p>                            <\/div>\r\n                        <\/div>\r\n                                        \r\n            <\/div>\r\n        \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b7a0bdc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b7a0bdc\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ef74a1f\" data-id=\"ef74a1f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3412be7 elementor-widget elementor-widget-menu-anchor\" data-id=\"3412be7\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"CovidProject\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4fce766a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4fce766a\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48244c86\" data-id=\"48244c86\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5c0a3424 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"5c0a3424\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2b338573\" data-id=\"2b338573\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d304c0e elementor-widget elementor-widget-text-editor\" data-id=\"d304c0e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p>Project Resume:<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e814c0 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"9e814c0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Design of mimetic proteins that block the fusion of SARS-CoV-2 with the host cell<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55f6453 elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"55f6453\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon elementor-animation-grow-rotate\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 510.974 510.974\" width=\"512\"><g><path d=\"m492.361 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4.745 3.953 10.728 5.744 16.852 5.04 3.861-.443 7.529-1.902 10.631-4.165l11.361 13.345c-10.498 18.937-17.455 39.337-20.709 60.723l-29.021 6.805c-3.523-8.792-12.047-15.16-22.011-15.423-6.487-.163-12.634 2.256-17.378 6.833-4.816 4.648-7.614 11.127-7.675 17.777l-.26 28.926c-.058 6.517 2.437 12.656 7.024 17.285s10.704 7.178 17.222 7.178c11.85.001 21.825-8.514 24.075-19.748z\"><\/path><path d=\"m219.962 230.442c3.659-1.939 5.054-6.479 3.114-10.139-1.939-3.658-6.477-5.056-10.14-3.114-17.923 9.5-38.352 6.989-48.569-5.975-5.733-7.272-7.705-16.909-5.553-27.134 2.256-10.722 8.708-20.733 18.167-28.188 9.457-7.456 20.699-11.386 31.65-11.082 10.445.295 19.354 4.463 25.088 11.736 8.608 10.921 8.499 27.222-.279 41.529-2.166 3.531-1.061 8.149 2.471 10.315 3.53 2.166 8.148 1.06 10.314-2.47 12.102-19.724 11.816-42.749-.727-58.66-8.533-10.826-21.476-17.021-36.443-17.443-14.464-.42-29.148 4.668-41.36 14.295-12.214 9.627-20.58 22.725-23.56 36.879-3.084 14.652-.082 28.684 8.451 39.509 8.985 11.398 23.054 17.394 38.19 17.393 9.643 0 19.718-2.432 29.186-7.451z\"><\/path><path d=\"m365.49 163.181c0-15.549-14.47-28.199-32.256-28.199s-32.257 12.65-32.257 28.199 14.471 28.199 32.257 28.199 32.256-12.65 32.256-28.199zm-49.512 0c0-7.278 7.741-13.199 17.257-13.199 9.515 0 17.256 5.921 17.256 13.199s-7.741 13.199-17.256 13.199c-9.516 0-17.257-5.921-17.257-13.199z\"><\/path><path d=\"m278.455 292.082c0-19.056-15.503-34.559-34.559-34.559-19.057 0-34.56 15.503-34.56 34.559s15.503 34.559 34.56 34.559c19.056 0 34.559-15.503 34.559-34.559zm-54.118 0c0-10.785 8.774-19.559 19.56-19.559 10.784 0 19.559 8.774 19.559 19.559s-8.774 19.559-19.559 19.559c-10.786 0-19.56-8.774-19.56-19.559z\"><\/path><path d=\"m376.229 277.985c0-14.819-12.056-26.875-26.875-26.875-14.818 0-26.874 12.056-26.874 26.875s12.056 26.875 26.874 26.875c14.819-.001 26.875-12.056 26.875-26.875zm-38.75 0c0-6.548 5.327-11.875 11.874-11.875 6.548 0 11.875 5.327 11.875 11.875s-5.327 11.875-11.875 11.875c-6.546-.001-11.874-5.327-11.874-11.875z\"><\/path><path d=\"m277.802 398.869c14.521 0 26.336-11.814 26.336-26.336 0-14.521-11.814-26.336-26.336-26.336s-26.337 11.814-26.337 26.336 11.814 26.336 26.337 26.336zm0-37.672c6.251 0 11.336 5.085 11.336 11.336s-5.085 11.336-11.336 11.336-11.337-5.085-11.337-11.336 5.086-11.336 11.337-11.336z\"><\/path><path d=\"m159.94 354.598c14.955 0 27.122-12.167 27.122-27.122s-12.167-27.122-27.122-27.122-27.122 12.167-27.122 27.122 12.167 27.122 27.122 27.122zm0-39.244c6.685 0 12.122 5.438 12.122 12.122s-5.438 12.122-12.122 12.122-12.122-5.438-12.122-12.122 5.438-12.122 12.122-12.122z\"><\/path><path d=\"m312.663 233.613c0-4.142-3.357-7.5-7.5-7.5h-6.63c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5h6.63c4.143 0 7.5-3.358 7.5-7.5z\"><\/path><path d=\"m210.025 372.213h6.812c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5h-6.812c-4.143 0-7.5 3.358-7.5 7.5s3.358 7.5 7.5 7.5z\"><\/path><path d=\"m146.88 262.991c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5h-6.562c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5z\"><\/path><path d=\"m280.087 131.774c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5h-9.132c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5z\"><\/path><path d=\"m329.979 332.797c-4.143 0-7.5 3.358-7.5 7.5s3.357 7.5 7.5 7.5h10.084c4.143 0 7.5-3.358 7.5-7.5s-3.357-7.5-7.5-7.5z\"><\/path><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30499145 elementor-widget elementor-widget-text-editor\" data-id=\"30499145\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><div id=\"Content\"><div class=\"boxed\"><div id=\"lipsum\"><p>The S protein of <strong>SARS-CoV-2<\/strong> promotes the adhesion of the virus to the host cell through the ACE2 receptor and its fusion with the cell membrane. The mechanism of this process, common to other retroviruses such as HIV, occurs through a conformational change of the S2 subunit in which two regions HR1 and HR2 interact, bringing the membranes closer together.<\/p><p>Blocking this process may be a promising strategy to prevent infection or block virus replication as both regions are highly conserved in the virus genome. Our group has previously designed recombinant proteins that mimic the HR1 region of HIV-1 and strongly interact with the HR2 region, inhibiting fusion. These proteins are <strong>potent inhibitors<\/strong> of HIV-1 infection.<\/p><p>Given the homology between the structures and interactions of the HR1 and HR2 regions of SARS-CoV-2 and HIV-1 and the similarity of their fusion mechanisms, we propose to apply a similar strategy to design and produce SARS-CoV-2 <strong>HR1 mimetic proteins<\/strong>, characterize them and test their inhibitory activities against virus infection in cell assays. In addition to their <strong>therapeutic potential<\/strong>, given that the main route of infection is through the respiratory tract, these molecules could be used in nasal inhalers as <strong>prophylactic agents<\/strong>.<\/p><\/div><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c76d0c6 elementor-widget elementor-widget-progress\" data-id=\"c76d0c6\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Project Progress<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper progress-success\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"100\" aria-valuetext=\"Progress\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"100\">\n\t\t\t\t<span class=\"elementor-progress-text\">Progress<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-progress-percentage\">100%<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4232612f elementor-align-center elementor-invisible elementor-widget elementor-widget-button\" data-id=\"4232612f\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#Video\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-left\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-video\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">learn more<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67c67ca1 elementor-section-content-middle elementor-section-full_width elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"67c67ca1\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-63883819 elementor-invisible\" data-id=\"63883819\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;animation&quot;:&quot;fadeInLeft&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a72367d elementor-view-default elementor-vertical-align-top elementor-widget elementor-widget-icon-box\" data-id=\"a72367d\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t<span >\u201c<\/span>\n\t\t\t\t<\/h3>\n\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">Upon infection HR1 undergoes a \u201cjackknife\u201d transition that can insert the fusion peptide (FP) into the target cell membrane\".<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c098 elementor-widget elementor-widget-text-editor\" data-id=\"c098\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p>SARS-CoV-2 Fusion Process<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-75a012ea elementor-invisible\" data-id=\"75a012ea\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInRight&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d7a0f5c elementor-widget elementor-widget-menu-anchor\" data-id=\"d7a0f5c\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"Video\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a77beb5 elementor-aspect-ratio-32 elementor-invisible elementor-widget elementor-widget-video\" data-id=\"a77beb5\" data-element_type=\"widget\" data-settings=\"{&quot;aspect_ratio&quot;:&quot;32&quot;,&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-wrapper elementor-fit-aspect-ratio elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen title=\"youtube Video Player\" src=\"https:\/\/www.youtube.com\/embed\/GFUzi4sbCJo?feature=oembed&amp;autoplay=1&amp;playsinline=1&amp;playlist=GFUzi4sbCJo&amp;wmode=opaque&amp;loop=1&amp;controls=1&amp;mute=0&amp;rel=0&amp;modestbranding=0\"><\/iframe>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-65e0d91 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"65e0d91\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-322f785\" data-id=\"322f785\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-725526a elementor-widget elementor-widget-menu-anchor\" data-id=\"725526a\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"Press\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf94c93 eael-dual-header-content-align-center elementor-widget elementor-widget-eael-dual-color-header\" data-id=\"cf94c93\" data-element_type=\"widget\" data-widget_type=\"eael-dual-color-header.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n                    <div class=\"eael-dual-header\">\n                                <h2 class=\"title\"><span class=\"lead\">Fresh from the <\/span> <span>Press (In the Media)<\/span><\/h2>\n                                <span class=\"subtext\"><p>Recently published information in the media about our COVID-19 research.<\/p><\/span>\n                            <\/div>\n        \n        \n        \n        \n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bd7c25e elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"bd7c25e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-68ccf86\" data-id=\"68ccf86\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0ddae64 elementor-widget elementor-widget-eael-image-accordion\" data-id=\"0ddae64\" data-element_type=\"widget\" data-widget_type=\"eael-image-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"eael-img-accordion accordion-direction-horizontal eael-img-accordion-horizontal-align-center eael-img-accordion-vertical-align-center\" data-img-accordion-id=\"0ddae64\" data-img-accordion-type=\"on-hover\" id=\"eael-img-accordion-0ddae64\"><a\n                    href=\"https:\/\/www.semicrobiologia.org\/wp-content\/uploads\/2026\/01\/SEM_80-4-Especial-MM-10.pdf\" target=\"_blank\" \n                    style=\"background-image: url(https:\/\/wpd.ugr.es\/~mariocano\/wordpress\/wp-content\/uploads\/2026\/02\/MCM_in_TKgroup.jpg); flex: 3 1 0%;\"\n                     class=\"overlay-active\"\n                >\n\t\t            <div class=\"overlay\">\n\t\t                <div class=\"overlay-inner\">\n                            <div class=\"overlay-inner overlay-inner-show\">\n                                <h2>A la caza de las se\u00f1ales reconocidas por receptores bacterianos<\/h2>\n                                <p><p>Art\u00edculo Sociedad Espa\u00f1ola de Microbiolog\u00eda (SEM@foro) - A la caza de las se\u00f1ales reconocidas por receptores bacterianos<\/p><\/p>\n                            <\/div>\n                        <\/div>\n\t\t            <\/div>\n\t\t          <\/a><a\n                    href=\"#\/\"  \n                    style=\"background-image: url(https:\/\/wpd.ugr.es\/~mariocano\/wordpress\/wp-content\/uploads\/2020\/10\/maxresdefault.jpg); flex: 3 1 0%;\"\n                     class=\"overlay-active\"\n                >\n\t\t            <div class=\"overlay\">\n\t\t                <div class=\"overlay-inner\">\n                            <div class=\"overlay-inner overlay-inner-show\">\n                                <h2>V\u00eddeo explicativo de nuestro proyecto de investigaci\u00f3n<\/h2>\n                                <p>Accordion content goes here!<\/p>\n                            <\/div>\n                        <\/div>\n\t\t            <\/div>\n\t\t          <\/a><a\n                    href=\"https:\/\/www.ideal.es\/granada\/batallon-cientificos-granada-coronavirus-20200406142547-nt.html\"  \n                    style=\"background-image: url(https:\/\/wpd.ugr.es\/~mariocano\/wordpress\/wp-content\/uploads\/2020\/10\/09_11.09.2020-Agenda-Covid-UGR-2.jpg);\"\n                    \n                >\n\t\t            <div class=\"overlay\">\n\t\t                <div class=\"overlay-inner\">\n                            <div class=\"overlay-inner\">\n                                <h2>Batall\u00f3n de cient\u00edficos de la UGR combaten la COVID-19 con sus investigaciones<\/h2>\n                                <p>Accordion content goes here!<\/p>\n                            <\/div>\n                        <\/div>\n\t\t            <\/div>\n\t\t          <\/a><a\n                    href=\"https:\/\/www.ideal.es\/miugr\/dedica-agenda-institucional-20201023143557-nt.html\"  \n                    style=\"background-image: url(https:\/\/wpd.ugr.es\/~mariocano\/wordpress\/wp-content\/uploads\/2020\/10\/05_11.09.2020-Agenda-Covid-UGR-2-e1603508760467.jpg);\"\n                    \n                >\n\t\t            <div class=\"overlay\">\n\t\t                <div class=\"overlay-inner\">\n                            <div class=\"overlay-inner\">\n                                <h2>Un batall\u00f3n de 70 cient\u00edficos granadinos contra el coronavirus<\/h2>\n                                <p>Accordion content goes here!<\/p>\n                            <\/div>\n                        <\/div>\n\t\t            <\/div>\n\t\t          <\/a><a\n                    href=\"https:\/\/www.lavanguardia.com\/vida\/20201024\/484265144094\/universidad-de-granada-dedica-su-agenda-del-curso-a-investigadores-de-covid.html\"  \n                    style=\"background-image: url(https:\/\/wpd.ugr.es\/~mariocano\/wordpress\/wp-content\/uploads\/2020\/10\/DSC5218_.jpg);\"\n                    \n                >\n\t\t            <div class=\"overlay\">\n\t\t                <div class=\"overlay-inner\">\n                            <div class=\"overlay-inner\">\n                                <h2>La UGR dedica su agenda institucional del curso 2020\/2021 a los cient\u00edficos que combaten el Covid-19<\/h2>\n                                <p>Accordion content goes here!<\/p>\n                            <\/div>\n                        <\/div>\n\t\t            <\/div>\n\t\t          <\/a><\/div><style typr=\"text\/css\">\n                    #eael-img-accordion-0ddae64 a:hover {\n                        flex: 3 1 0% !important;\n                    }\n         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elementor-element-73763a11\" data-id=\"73763a11\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ba4466b elementor-arrows-position-outside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"3ba4466b\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;4&quot;,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;slides_to_show_tablet&quot;:&quot;3&quot;,&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div 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src=\"https:\/\/wpd.ugr.es\/~mariocano\/wordpress\/wp-content\/uploads\/elementor\/thumbs\/Logo-EEZ-qwh7xqbwim1w9tggke6r0aj2iu62wnuamaj9bx0xc0.png\" alt=\"Logo-EEZ\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\">\n\t\t\t\t\t\t<i class=\"eicon-chevron-left\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Previous<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\">\n\t\t\t\t\t\t<i class=\"eicon-chevron-right\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Next<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-09b4a98 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"09b4a98\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-23ef2be\" data-id=\"23ef2be\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12ef039 elementor-widget elementor-widget-spacer\" data-id=\"12ef039\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>COVID-19 ResearcH Our Research Project We are currently undergoing a Research Project called: Design of mimetic proteins that block the fusion of SARS-Cov-2 with the host cell. learn more S1 S1 subunit contains a receptor binding domain (RBD), which is responsible for recognizing and binding with the cell surface receptor. S2 S2 subunit contains other &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/wpd.ugr.es\/~mariocano\/covid-19\/\"> <span class=\"screen-reader-text\">COVID-19<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":[],"_links":{"self":[{"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/pages\/434"}],"collection":[{"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/comments?post=434"}],"version-history":[{"count":167,"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/pages\/434\/revisions"}],"predecessor-version":[{"id":905,"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/pages\/434\/revisions\/905"}],"wp:attachment":[{"href":"https:\/\/wpd.ugr.es\/~mariocano\/wp-json\/wp\/v2\/media?parent=434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}