Metals & Artificial Nucleobases

One of our goals is to understand how the metal ions and coordination compounds that we use in our research interact with bases (natural and artificial) in oligonucleotide sequences. This knowledge, together with the help of computational calculations, can allow us to estimate the most suitable DNA-metal structures and to be able to design sequences adapted to our purposes. For this reason, we carry out the synthesis of metal-nucleobase complexes and characterize them both in the liquid phase (NMR, UV-Vis, fluorescence, ESI-MS) and in the solid-state (single-crystal XRD, XRD in pols, IR, elemental analysis).