About Me
I’m a biochemist with two Master´s Degrees. Ph.D. in Chemistry. My professional interests are Computational Modelling and Simulation with emphasis in Protein Engineering and Design.
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2024
Gómez‐Mulas, A., Cano‐Muñoz, M., Salido Ruiz, E., & Pey, A. L. (2024). Thermodynamic versus kinetic basis for the high conformational stability of nanobodies for therapeutic applications. FEBS letters.
Pacheco‐García, J. L., Cano‐Muñoz, M., Loginov, D. S., Vankova, P., Man, P., & Pey, A. L. (2024). Phosphorylation of cytosolic hPGK1 affects protein stability and ligand binding: implications for its subcellular targeting in cancer. The FEBS Journal.
Pérez‐Romero, A., Cano‐Muñoz, M., López‐Chamorro, C., Conejero‐Lara, F., Palacios, O., Dobado, J. A., & Galindo, M. A. (2024). Selective Formation of Pd‐DNA Hybrids Using Tailored Palladium‐Mediated Base Pairs: Towards Heteroleptic Pd‐DNA Systems. Angewandte Chemie, 136(11), e202400261.
Polo-Megías, D., Cano-Muñoz, M., Berruezo, A. G., Laumond, G., Moog, C., & Conejero-Lara, F. (2024). Investigating vulnerability of the conserved SARS-CoV-2 spike's heptad repeat 2 as target for fusion inhibitors using chimeric miniproteins. International Journal of Biological Macromolecules, 262, 130132.
2022
Polo-Megías, D., Cano-Muñoz, M., Berruezo, A. G., Laumond, G., Moog, C., & Conejero-Lara, F. (2022). Exploring Highly Conserved Regions of SARS-CoV-2 Spike S2 Subunit as Targets for Fusion Inhibition Using Chimeric Proteins. International Journal of Molecular Sciences, 23(24), 15511.
Cano-Muñoz, M., Polo-Megías, D., Cámara-Artigas, A., Gavira, J. A., López-Rodríguez, M. J., Laumond, G., ... & Conejero-Lara, F. (2022). Novel chimeric proteins mimicking SARS-CoV-2 spike epitopes with broad inhibitory activity. International journal of biological macromolecules.
Pacheco-García, J. L., Loginov, D. S., Naganathan, A. N., Vankova, P., Cano-Muñoz, M., Man, P., & Pey, A. L. (2022). Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core. Scientific Reports, 12(1), 1-17.
Cano-Muñoz, M.; Lucas, J.; Lin, L.-Y.; Cesaro, S.; Moog, C.; Conejero-Lara, F. Conformational Stabilization of Gp41-Mimetic Miniproteins Opens Up New Ways of Inhibiting HIV-1 Fusion. Int. J. Mol. Sci. 2022, 23, 2794.
2021
Cano-Muñoz, M.; Jurado, S.; Morel, B.; Conejero-Lara, F. Conformational flexibility of the conserved hydrophobic pocket of HIV-1 gp41. Implications for the discovery of small-molecule fusion inhibitors. International Journal of Biological Macromolecules 192 (2021) 90–99
Cano-Muñoz, M.; Cesaro, S.; Morel, B.; Lucas, J.; Moog, C.; Conejero-Lara, F. Extremely Thermostabilizing Core Mutations in Coiled-Coil Mimetic Proteins of HIV-1 gp41 Produce Diverse Effects on Target Binding but Do Not Affect Their Inhibitory Activity. Biomolecules 2021, 11, 566.
2020
Pacheco-García, J.L.; Cano-Muñoz, M.; Sánchez-Ramos, I.; Salido, E.; Pey, A.L. Naturally-Occurring Rare Mutations Cause Mild to Catastrophic Effects in the Multifunctional and Cancer-Associated NQO1 Protein. J. Pers. Med. 2020, 10, 207.
Jurado, S.; Moog, C.; Cano-Muñoz, M.; Schmidt, S.; Laumond, G.; Ruocco, V.; Standoli, S.; Polo-Megías, D.; Conejero-Lara, F.; Morel, B. Probing Vulnerability of the gp41 C-Terminal Heptad Repeat as Target for Miniprotein HIV Inhibitors. J. Mol. Biol. 2020, 432, 5577–5592.
Jurado, S., Cano-Muñoz, M., Polo-Megías, D., Conejero-Lara, F., & Morel, B. (2020). Thermodynamic dissection of the interface between HIV-1 gp41 heptad repeats reveals cooperative interactions and allosteric effects. Archives of Biochemistry and Biophysics, 108401.
2019
Medina-O’Donnell, M., Rivas, F., Reyes-Zurita, F. J., Cano-Muñoz, M., Martinez, A., Lupiañez, J. A., & Parra, A. (2019). Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease. Journal of natural products, 82(10), 2886-2896.
Jurado, S., Cano-Muñoz, M., Morel, B., Standoli, S., Santarossa, E., Moog, C., ... & Conejero-Lara, F. (2019). Structural and Thermodynamic Analysis of HIV-1 Fusion Inhibition Using Small gp41 Mimetic Proteins. Journal of molecular biology, 431(17), 3091-3106.
- (+34) 958 240437
- mariocano@ugr.es
- Avenida de Fuente Nueva, s/n, 18071, Granada (Spain). Department of Physical Chemistry.