Mario Cano

Posdoctoral Research Scientist. Ph.D. Biochemist.

About Me

I’m a biochemist with two Master´s Degrees. Ph.D. in Chemistry. My professional interests are Computational Modelling and Simulation with emphasis in Protein Engineering and Design.

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Publications

I publish my research in high impact peer-reviewed scientific journals

Scientific Illustrations

I believe in the power of making science with art as an accurate way to inform and communicate scientific topics

Molecular 3D Print

Tangible molecular models are the perfect way to visualize scientific data that help understanding and sharing complex subjects

Publications

ORCiD | Google Scholar Profile | University Page

2022

Polo-Megías, D., Cano-Muñoz, M., Berruezo, A. G., Laumond, G., Moog, C., & Conejero-Lara, F. (2022). Exploring Highly Conserved Regions of SARS-CoV-2 Spike S2 Subunit as Targets for Fusion Inhibition Using Chimeric Proteins. International Journal of Molecular Sciences, 23(24), 15511.

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Cano-Muñoz, M., Polo-Megías, D., Cámara-Artigas, A., Gavira, J. A., López-Rodríguez, M. J., Laumond, G., ... & Conejero-Lara, F. (2022). Novel chimeric proteins mimicking SARS-CoV-2 spike epitopes with broad inhibitory activity. International journal of biological macromolecules.

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Pacheco-García, J. L., Loginov, D. S., Naganathan, A. N., Vankova, P., Cano-Muñoz, M., Man, P., & Pey, A. L. (2022). Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core. Scientific Reports, 12(1), 1-17.

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Cano-Muñoz, M.; Lucas, J.; Lin, L.-Y.; Cesaro, S.; Moog, C.; Conejero-Lara, F. Conformational Stabilization of Gp41-Mimetic Miniproteins Opens Up New Ways of Inhibiting HIV-1 Fusion. Int. J. Mol. Sci. 2022, 23, 2794.

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2021

Cano-Muñoz, M.; Jurado, S.; Morel, B.; Conejero-Lara, F. Conformational flexibility of the conserved hydrophobic pocket of HIV-1 gp41. Implications for the discovery of small-molecule fusion inhibitors. International Journal of Biological Macromolecules 192 (2021) 90–99

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Cano-Muñoz, M.; Cesaro, S.; Morel, B.; Lucas, J.; Moog, C.; Conejero-Lara, F. Extremely Thermostabilizing Core Mutations in Coiled-Coil Mimetic Proteins of HIV-1 gp41 Produce Diverse Effects on Target Binding but Do Not Affect Their Inhibitory Activity. Biomolecules 2021, 11, 566.

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2020

Pacheco-García, J.L.; Cano-Muñoz, M.; Sánchez-Ramos, I.; Salido, E.; Pey, A.L. Naturally-Occurring Rare Mutations Cause Mild to Catastrophic Effects in the Multifunctional and Cancer-Associated NQO1 Protein. J. Pers. Med. 2020, 10, 207.

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Jurado, S.; Moog, C.; Cano-Muñoz, M.; Schmidt, S.; Laumond, G.; Ruocco, V.; Standoli, S.; Polo-Megías, D.; Conejero-Lara, F.; Morel, B. Probing Vulnerability of the gp41 C-Terminal Heptad Repeat as Target for Miniprotein HIV Inhibitors. J. Mol. Biol. 2020, 432, 5577–5592.

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Jurado, S., Cano-Muñoz, M., Polo-Megías, D., Conejero-Lara, F., & Morel, B. (2020). Thermodynamic dissection of the interface between HIV-1 gp41 heptad repeats reveals cooperative interactions and allosteric effects. Archives of Biochemistry and Biophysics, 108401.

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2019

Medina-O’Donnell, M., Rivas, F., Reyes-Zurita, F. J., Cano-Muñoz, M., Martinez, A., Lupiañez, J. A., & Parra, A. (2019). Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease. Journal of natural products, 82(10), 2886-2896.

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Jurado, S., Cano-Muñoz, M., Morel, B., Standoli, S., Santarossa, E., Moog, C., ... & Conejero-Lara, F. (2019). Structural and Thermodynamic Analysis of HIV-1 Fusion Inhibition Using Small gp41 Mimetic Proteins. Journal of molecular biology, 431(17), 3091-3106.

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