Category Archives: Metabolomics

HILIC-MS and CE-MS as complementary analytical approaches to assess the impact of exposure to polychlorinated biphenyls on the polar serum metabolome of pigs.

Posted on 7 October, 2024 by fqm302

Hydrophilic interaction liquid chromatography (HILIC) and capillary electrophoresis (CE) coupled to mass spectrometry (MS) are two of the most widely used techniques to explore and characterize the polar metabolome. Both platforms have some peculiar characteristics that make them more suitable … Continue reading →

Posted in Exposomics, HILIC, Metabolomics, PID2020–120020RA-I00, PROYEXCEL_00195, Pig serum, Polychlorinated biphenyls | Tagged , , , | Comments Off on HILIC-MS and CE-MS as complementary analytical approaches to assess the impact of exposure to polychlorinated biphenyls on the polar serum metabolome of pigs.

Determination of bile acids in serum of pigs exposed to polychlorinated biphenyls by liquid chromatography-mass spectrometry.

Posted on 22 December, 2023 by fqm302

Exposure to polychlorinated biphenyls (PCBs) has been linked to dyslipidemia. Under acute exposure to PCBs, it has been observed that the secretion of bile acids (BAs) can be impacted, limiting (indirectly) lipid absorption in the gut. In this context, two … Continue reading →

Posted in Liquid-liquid extraction, Mass spectrometry, Metabolomics, PID2020–120020RA-I00, Pig serum, Polychlorinated biphenyls, UHPLC | Tagged , , , | Comments Off on Determination of bile acids in serum of pigs exposed to polychlorinated biphenyls by liquid chromatography-mass spectrometry.

Deeper insights into the effects of low dietary levels of polychlorinated biphenyls on pig metabolism using gas chromatography-high resolution mass spectrometry metabolomics.

Posted on 6 September, 2023 by fqm302

Polychlorinated biphenyls (PCBs) are a class of contaminants of great concern, linked to the development of many chronic diseases. Adverse effects of PCBs have been documented in humans after accidental and massive exposure. However, little is known about the effect … Continue reading →

Posted in Contaminants, GC, Mass spectrometry, Metabolomics, PID2020–120020RA-I00, Pig serum, Polychlorinated biphenyls | Tagged , , | Comments Off on Deeper insights into the effects of low dietary levels of polychlorinated biphenyls on pig metabolism using gas chromatography-high resolution mass spectrometry metabolomics.

A comparison of hydrophilic interaction liquid chromatography and capillary electrophoresis for the metabolomics analysis of human serum.

Posted on 6 August, 2023 by fqm302

Cationic, anionic, zwitterionic and, partially polar metabolites are very important constituents of blood serum. Several of these metabolites underpin the core metabolism of cells (e.g., Krebs cycle, urea cycle, proteins synthesis, etc.), while others might be considered ancillary but still … Continue reading →

Posted in CZE, HILIC, Human serum, Metabolomics, PID2020–120020RA-I00, PROYEXCEL_00195 | Tagged , , | Comments Off on A comparison of hydrophilic interaction liquid chromatography and capillary electrophoresis for the metabolomics analysis of human serum.